DNA methyltransferase Dnmt1 associates with histone deacetylase activity

By François Fuks, W. Burgers, A. Brehm, L. Hughes-Davies, Tony Kouzarides. Nature Genetics, 2000

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DNA Methylation and Its Basic Function (2013, background): “Furthermore, Dnmt1 and Dnmt3b can both bind to histone deacetylases that remove acetylation from histones to make DNA pack more tightly and restrict access for transcription (Fuks et al, 2000; Geiman et al, 2004).”
Development of type 2 diabetes following intrauterine growth retardation in rats is associated with progressive epigenetic silencing of Pdx1. (2008, background): “Our observation that inhibition of HDAC activity by TSA treatment normalized H3K4me3 levels at Pdx1 in IUGR islets suggests that the association of HDAC1 at Pdx1 in IUGR islets likely serves as a platform for the recruitment of a demethylase, which catalyzes demethylation of H3K4.”
CpG island hypermethylation and tumor suppressor genes: a booming present, a brighter future (2002, background): “The last piece in the epigenetic jigsaw is provided by the finding that the DNA methyltransferases themselves are also associated with HDAC activities (Fuks et al., 2000; Robertson et al., 2000).”
Human SIR2 deacetylates p53 and antagonizes PML/p53‐induced cellular senescence (2002, methodology): “TNT system (Promega) and binding assays were performed as described previously (Fuks et al., 2000).”
The DNA methyltransferases associate with HP1 and the SUV39H1 histone methyltransferase. (2003, methodology): “DNA methyltransferase assays were performed as described before (7).”