CpG island hypermethylation and tumor suppressor genes: a booming present, a brighter future

By Manel Esteller. Oncogene, 2002

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The role of histone deacetylases (HDACs) in human cancer (2007, background): “1574-7891/$ – see front matter ª 2007 Federation of European Bioc doi:10.1016/j.molonc.2007.01.001 human tumors (Esteller, 2002).”
High-throughput DNA methylation profiling using universal bead arrays. (2006, background): “…and apoptosis; genes considered to be targets for oncogenic transformation; genes of innate host defense; genes involved in surfactant function of the lung; imprinted genes; and previously reported differentially methylated genes (Adorjan et al. 2002; Esteller 2002; Tsou et al. 2002).”
Comparison of Beta-value and M-value methods for quantifying methylation levels by microarray analysis (2010, background): “Hypermethylation of CpG islands located in the promoter regions of tumor suppressor genes has been firmly established as one of the most common mechanisms for gene regulation in cancer [2,3].”
Genetics of adult glioma. (2012, background): “Promoter CpG island hypermethylation, G-CIMP or Glioma CpG Island Hypermethylation, has been shown in many cancers and widely reported in glioma (24,26,27).”