Tumor-derived lactic acid modulates dendritic cell activation and antigen expression.

By E. Gottfried, Leoni A. Kunz-Schughart, S. Ebner, W. Mueller‐Klieser, S. Hoves, R. Andreesen, Andreas Mackensen, M. Kreutz. Blood, 2006

692 citations recorded by the source corpus.

Subfields: Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/9570bc52f63a73d4f90c5f459ceed878e08f3f53

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. D. Gabrilovich
2. S. Ostrand-Rosenberg
3. V. Bronte
4. B. Ruffell
5. Alycia Gardner
6. J. Rathmell
7. A. Mantovani
8. P. Sinha

In Oncology

1. D. Gabrilovich
2. S. Ostrand-Rosenberg
3. V. Bronte
4. G. Brooks
5. B. Ruffell
6. A. Mantovani

Citations in the corpus

• Tumor-Derived Lactate Modifies Antitumor Immune Response: Effect on Myeloid-Derived Suppressor Cells and NK Cells (2013, background): “Lactate/low pH also alters the Ag-presenting ability of dendritic cells (29), inhibits cytotoxic activity (30), and promotes IL-23/IL-17 proinflammatory pathway (31).”
• Regulation of glycolysis by the hypoxia‐inducible factor (HIF): implications for cellular physiology (2020, background): “Tumour-derived lactic acid also alters the antigen-presenting capacity and cytokine production of human monocyte-derived DCs (Gottfried et al. 2006) and inhibits monocyte activation, migration and cytokine release (Dietl et al.”
• Multicellular tumor spheroids: an underestimated tool is catching up again. (2010, methodology): “It was shown that lactic acid modulates the differentiation of monocytes into dendritic cells and alters antigen expression (Gottfried et al., 2006).”
• Dendritic Cells and Cancer Immunity (2016, background): “For example, hypoxia and lactic acid regulate macrophage function within tumors [58, 59] and suppress DC activation in vitro [60, 61].”
• Acidic extracellular microenvironment and cancer (2013, background): “Lactate inhibits dendritic cell activation during antigen-specific autologous T-cell stimulation [12].”
• The Science and Translation of Lactate Shuttle Theory. (2018, background): “Further, 774 Cell Metabolism 27, April 3, 2018 lactate inhibits the differentiation of monocytes to dendritic cells (Gottfried et al., 2006; Puig-Kröger et al., 2003).”
• Targeting Metabolism to Improve the Tumor Microenvironment for Cancer Immunotherapy. (2020, background): “First, lactate inhibits monocyte activation and dendritic cell differentiation (Gottfried et al., 2006; Nasi et al., 2013) and promotes M2polarization through increased arginase and HIF-1α stabilization (Colegio et al.”