Hypoxia-inducible factor-1 (HIF-1).

By P. Schumacker. Critical Care Medicine, 2005

827 citations recorded by the source corpus.

Subfields: Cancer Research, Genetics, Neurology

View Paper: https://www.semanticscholar.org/paper/956fa8792357f8764e3aeb6b3f595f22895cfbb7

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. R. Guzy
2. P. Schumacker
3. Georgina N. Masoud
4. Wei Li
5. G. Han
6. R. Ceilley
7. C. A. Dinarello
8. Luke A. O'Neill

In Genetics

1. R. Guzy
2. Georgina N. Masoud
3. Wei Li
4. G. Han
5. R. Ceilley
6. P. Schumacker
7. Mihai G. Netea
8. C. A. Dinarello

In Neurology

1. Georgina N. Masoud
2. Wei Li
3. G. Han
4. R. Ceilley
5. R. Guzy
6. Mihai G. Netea
7. F. L. van de Veerdonk

Citations in the corpus

• Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained Immunity (2016, methodology): “Incubation of humanmonocytes with fumarate for 2 hr in- hibited HIF1a hydroxylation (Figure 5A), and HIF1a targets (Ke and Costa, 2006) were induced on a transcriptional level (Fig- ure 5B).”
• HIF-1α pathway: role, regulation and intervention for cancer therapy (2015, background): “Temsirolimus (Torisels– CCI-779, 4), and its counterparts, everolimus or rad001 (Afinitors, 4a) and sirolimus (Rapamycins, 4b) are mTOR inhibitors currently in clinical development for the treatment of solid tumors57.”
• Chronic Wound Healing: A Review of Current Management and Treatments (2017, background): “A moist occlusive dressinghelps support the inflammatoryphase by creating an environment with low oxygen tension (thereby activating such factors as hypoxia-inducible factor-1) [39] and also increases the rate of re-epithelialization [40].”
• Oxygen sensing by mitochondria at complex III: the paradox of increased reactive oxygen species during hypoxia (2006, background): “The fact that PH utilizes O2 as a substrate raises the question of whether PH functions as the O2 sensor regulating HIF activation (Kaelin, 2003, 2005; Schumacker, 2005).”
• The Role of the PERK/eIF2α/ATF4/CHOP Signaling Pathway in Tumor Progression During Endoplasmic Reticulum Stress (2016, background): “Overexpression of HIF-1 has been reported in many types of cancers as one of the cellular responses to hypoxic stress conditions that results in adaptation of the cancer cells to oxygen deprivation [47].”