Biosynthesis of Complex Polyketides in a Metabolically Engineered Strain of E. coli

By B. Pfeifer, S. J. Admiraal, H. Gramajo, D. Cane, C. Khosla. Science, 2001

714 citations recorded by the source corpus.

Subfields: Molecular Biology, Organic Chemistry, Pharmacology

View Paper: https://www.semanticscholar.org/paper/9518e893a2da03c0f7b3e9541976de41fa28d01d

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. Michael A. Fischbach
2. Marnix H. Medema
3. Eriko Takano
4. Andrej Sali
5. C. Walsh
6. Peter Cimermancic
7. Amrita Pati
8. Bruce W. Birren

In Organic Chemistry

1. C. Walsh
2. Jon Clardy

In Pharmacology

1. Michael A. Fischbach
2. Marnix H. Medema
3. Eriko Takano
4. Jon Clardy
5. C. Walsh
6. Kim Lewis
7. Tilmann Weber
8. Kai Blin

Citations in the corpus

• New antibiotics from bacterial natural products (2006, background): “coli and Pseudomonas putida ) expressing drug candidates and other small molecules, and further progress on more metabolically versatile hosts is likel”
• Insights into secondary metabolism from a global analysis of prokaryotic biosynthetic gene clusters. (2014, methodology): “Although some BGCs are so well understood that the biosynthesis of their small molecule product has been reconstituted in heterologous hosts (Pfeifer et al., 2001) or in vitro using purified enzymes (Lowry (A) Flowchart of the four-step BGC prediction pipeline: (1) annotation of a genome sequence…”