The Notch ligand Delta-like 4 negatively regulates endothelial tip cell formation and vessel branching

By S. Suchting, Catarina Freitas, F. le Noble, Rui Benedito, C. Bréant, A. Duarte, A. Eichmann. Proceedings of the National Academy of Sciences of the United States of America, 2007

857 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/94f4bbb6f1f68e8bfe54b53145b1f1722b59903b

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Citations in the corpus

• The notch ligands Dll4 and Jagged1 have opposing effects on angiogenesis. (2009, positive): “The ligand Dll4, a transmembrane protein, is upregulated by VEGF in the angiogenic vasculature (Hainaud et al., 2006; Hellstrom et al., 2007; Lobov et al., 2007; NogueraTroise et al., 2006; Suchting et al., 2007).”
• Notch signalling in solid tumours: a little bit of everything but not all the time (2011, background): “DLL4 on the tip cells signals through Notch on the adjacent tube cells to decrease VEGF-induced sprouting and branching by downregulating VEGF receptor 2 (VEGFR2”
• Targeting cancer stem cells by inhibiting Wnt, Notch, and Hedgehog pathways (2011, background): “whereas heterozygous deletion of DLL4 is in general lethal”