Notch signalling in solid tumours: a little bit of everything but not all the time

By Prathibha Ranganathan, Kelly L. Weaver, A. Capobianco. Nature Reviews. Cancer, 2011

823 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/f06625ef06b25de2f81f3515bbd73d39d3bae94e

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In Molecular Biology

In Oncology

J. Slingerland

Citations in the corpus

Targeting cancer stem cell pathways for cancer therapy (2020, background): “181 Different tumors and tumor subtypes express different Notch ligands and receptors.”
Angiogenic signaling pathways and anti-angiogenic therapy for cancer (2023, background): “3).278 Notch is initially verified in Drosophila melanogaster in the mid-1980s and is a highly evolutionarily conserved local signaling pathway.278 In mammals, the Notch receptors can be divided into four subunits named Notch-1, Notch-2, Notch-3 and Notch-4, and five ligands have been discovered, in”
Exosome transfer from stromal to breast cancer cells regulates therapy resistance pathways. (2014, background): “Both antiviral and NOTCH signaling have roles in controlling normal and cancer stem cells (Baldridge et al., 2010; Ranganathan et al., 2011).”
Mechanisms of chemoresistance in cancer stem cells (2013, background): “The Notch signaling pathway has been identified to play an important role in a number of processes during tumor progression and metastases including tumor initiation, angiogenesis, epithelial-mesenchymal transition (EMT)-driven metastatic growth as well as selfrenewal of cancer stem cells [78].”
Sol-gel based materials for biomedical applications (2016, background): “Lindén and co-workers have delivered c-secretase inhibitors (GSIs) encapsulated into folate bioconjugated PEI coated MSNs to inhibit Notch signaling, which plays a significant role in tumor angiogenesis, maintenance and progression, and is a specific cancer stem cell signaling for maintaining stem c”
iNOS promotes CD24+CD133+ liver cancer stem cell phenotype through a TACE/ADAM17-dependent Notch signaling pathway (2018, background): “Notch signaling promotes the progression of solid cancers (22) by driving angiogenesis (23) and maintaining a population of undifferentiated CSCs.”