Differential Regulation of Nitric Oxide Synthase-2 and Arginase-1 by Type 1/Type 2 Cytokines In Vivo: Granulomatous Pathology Is Shaped by the Pattern of l-Arginine Metabolism1

By M. Hesse, M. Modolell, A. L. La Flamme, M. Schito, J. M. Fuentes, A. Cheever, Edward J. Pearce, TA Wynn. Journal of Immunology, 2001

648 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/94f41495ff0dad8398cfff5e530052c6e7f651a4

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. TA Wynn
2. S. Gordon
3. F. Martínez
4. Xia Zhang
5. R. Locksley
6. S. V. Van Dyken
7. J. Edwards
8. D. Mosser

In Molecular Biology

1. Luke Barron
2. J. Suttles
3. S. Gordon
4. Alok Kumar
5. F. Martínez
6. David J. Loane
7. TA Wynn
8. M. Munder

In Physiology

1. R. Locksley
2. S. Gordon
3. Alok Kumar
4. David J. Loane
5. TA Wynn
6. M. Munder

Citations in the corpus

• Macrophages: Master Regulators of Inflammation and Fibrosis (2010, background): “Given the presumably important contribution of AAMw to the development of fibrosis, a great deal of recent research has sought to identify the signals that regulate their activation and recruitment to sites of inflammation, with IL4, IL-13, IL-10, granulocyte-macrophage colony-stimulating factor, IL”
• Interleukin‐13 in asthma pathogenesis (2004, background): “Evidence of an in vivo role for this pathway in tissue fibrosis was provided by Hesse and colleagues (57).”
• The many faces of macrophage activation (2003, background): “The in vivo schistosome infection model has proven to be an invaluable one to unravel the function of altered macrophage metabolism caused by type 2 cytokines [28].”
• Biochemical and functional characterization of three activated macrophage populations (2006, background): “These cells are associated with parasitic diseases [8] and may contribute to the production of the extracellular matrix (ECM) [9].”
• Mechanisms of fibrosis: therapeutic translation for fibrotic disease (2012, neutral): “Expression of Arg1 by M2 cells is of particular interest because this enzyme controls l-proline production, which is required for collagen synthesis by activated N I H - PA A u t ho r M anu sc r i p t N I H - PA A u t ho r M anu sc r i p t N I H - PA A u t ho r M anu sc r i p t myofibroblasts 41 .”
• Microglia in the TBI Brain: The Good, The Bad, And The Dysregulated (2015, background): “…after a rapid pro-inflammatory response that is driven byM2like macrophages has been demonstrated to result in fibrosis and other aberrant repair (Hesse et al., 2001), because elevated arginase activity shifts themetabolism of L-arginine significantly to produce increased ornithine and proline…”
• Macrophages, Foreign Body Giant Cells and Their Response to Implantable Biomaterials (2015, background): “While wound repair is generally beneficial, when there is dysregulated activity by the wound repairing macrophages, tissue fibrosis may occur [43].”