PI(3,4,5)P3 and PI(4,5)P2 Lipids Target Proteins with Polybasic Clusters to the Plasma Membrane

By W. Heo, Takanari Inoue, W. Park, Man Lyang Kim, Byung Ouk Park, T. Wandless, T. Meyer. Science, 2006

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Molecular Basis of Calcium Signaling in Lymphocytes: STIM and ORAI (2010, background): “Experience with other proteins indicates that it may be necessary to deplete both PIP2 and PIP3 to alter localization (114).”
PIP2 is a necessary cofactor for ion channel function: how and why? (2008, background): “The GTPases leave the plasma membrane when PIP2 is hydrolyzed—or if some of their basic or hydrophobic residues are mutated (26).”
Phosphoinositides: tiny lipids with giant impact on cell regulation. (2013, background): “Good examples are the MARCKS proteins (1670) and the K-Ras COOH terminus (601), but many other proteins show membrane association using this mechanism.”
SYMPOSIUM REVIEW: Phosphoinositides: lipid regulators of membrane proteins (2010, unknown): “In other proteins, including the small GTPases, a cytoplasmic polybasic region rather than a recognizable known domain fold interacts with the phosphoinositides (Heo et al. 2006).”