Inflammatory Blockade Restores Adult Hippocampal Neurogenesis

By Michelle Monje, H. Toda, T. Palmer. 2003

2,443 citations recorded by the source corpus.

Subfields: Developmental Neuroscience, Neurology

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Citations in the corpus

Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions (2011, background): “…fate commitment of neural progenitors in the adult SGZ but also disrupts the local niche with aberrant angiogenesis and increasing number of reactivated microglia cells, resulting in sustained inhibition of neurogenesis from both endogenous and transplanted neural progenitors (Monje et al., 2003).”
Experimental autoimmune encephalomyelitis repressed by microglial paralysis (2005, background): “Recent reports suggest an inverse relationship between microglial activation and neurogenesi”
Immune modulation of learning, memory, neural plasticity and neurogenesis. (2011, positive): “revealed marked suppression of NPCs proliferation, including reduced neurogenesis (Ben-Hur et al., 2003; Monje et al., 2003).”
The potential of neural stem cells to repair stroke-induced brain damage (2009, background): “Neurogenesis prevented by inXammation can be restored by treatment with antibodies against the proinXammatory cytokine interleukin-6 [ 78 ] as well as with anti-inXammatory compounds such as indomethacin and minocycline [34, 50, 69].”
Microglia regulate the number of neural precursor cells in the developing cerebral cortex (2013, methodology): “…doxycycline and minocycline can reduce microglial activation, along with previous studies showing similar results in the adult hippocampus (Ekdahl et al., 2003; Monje et al., 2003), suggest the possibility that pharmacological agents could attenuate the impact of MIA on the developing fetal brain.”
Microglia shape adult hippocampal neurogenesis through apoptosis-coupled phagocytosis (2010, background): “Initial reports suggested that inflammation, resulting from activation of microglia by irradiation or administration of high doses of LPS, is detrimental for neurogenesis (Ekdahl et al., 2003a; Monje et al., 2003).”
Immune cells contribute to the maintenance of neurogenesis and spatial learning abilities in adulthood (2006, background): “Previous studies have distinguished between liposaccharide (LPS)-activated microglia (the classically activated microglia that apparently impair neurogenesis; ref”
Evidence for reduced neurogenesis in the aging human hippocampus despite stable stem cell markers (2017, background): “, 2002), inflammatory blockade (Monje et al., 2003; Ormerod et al., 2013; Speisman et al., 2013) or hormonal modulation (Montaron et al.”
Functions and mechanisms of microglia/macrophages in neuroinflammation and neurogenesis after stroke. (2016, background): “Similar fates of new hippocampal neurons have been demonstrated in an inflammatory milieu (Monje et al., 2003).”
The inflammatory & neurodegenerative (I&ND) hypothesis of depression: leads for future research and new drug developments in depression (2009, background): “Moreover, treatment with inflammatory cytokine inducers, including LPS and radiation, resulted in marked suppression of hippocampal neurogenesis (Ekdahl et al. 2003; Monje et al. 2003).”