Scatter-factor and semaphorin receptors: cell signalling for invasive growth

By Livio Trusolino, P. Comoglio. Nature Reviews. Cancer, 2002

786 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology, Pharmacology

View Paper: https://www.semanticscholar.org/paper/93e342961efbc4cc4d888cfa2866631c62884ce3

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Citations in the corpus

Mathematical modelling of cancer cell invasion of tissue (2005, background): “The pathways involved in tumour-growth can be classified as: intracellular, such as the formation of actin filaments to produce pseudopodia; extracellular, for example the reorganization of the collagen filaments of the ECM; and certain others that connect intracellular dynamics with the extracellul”
To move or not to move? (2004, background): “It was suggested that these plexins sequester activated Rac and antagonize its signalling pathway (Hu et al, 2001; Vikis et al, 2002).”
An overview of the c-MET signaling pathway (2011, background): “HGF acts as a pleiotropic factor and cytokine, promoting cell proliferation, survival, http://tam.sagepub.com S7 motility, scattering, differentiation and morphogenesis [Basilico et al. 2008; Birchmeier et al. 2003; Trusolino and Comoglio, 2002].”
Drug development of MET inhibitors: targeting oncogene addiction and expedience (2008, background): “jpg" NDATA ITEM> ]> The MET tyrosine kinase is a cell surface receptor for hepatocyte growth factor ( HGF , also known as scatter factor), a pleiotropic cytokine that conveys a unique combination of pro-migratory, anti-apoptotic and mitogenic signal”
Axis of evil: molecular mechanisms of cancer metastasis (2003, background): “Generally speaking, SF/HGF stimulates the facets of invasive growth in virtually every tissue of the body (reviewed in Trusolino and Comoglio, 2002; Zhang and Vande Woude, 2003).”
Stromal fibroblasts in cancer initiation and progression (2004, background): “Overexpression and activation of c-Met is a common event in human cance”
MET signalling: principles and functions in development, organ regeneration and cancer (2010, background): “To do so, MET propagates an intricate system of signalling cascades that result in a comprehensive rewiring of gene expressio”
New signals from the invasive front (2006, background): “HGF, which is produced mainly by stromal cells, and the c-Met receptor tyrosine kinase (RTK), its cognate receptor on tumour cells, are key mediators of invasive growth during embryonic development and tumour progressio”