TLR3 Deficiency in Patients with Herpes Simplex Encephalitis

By Shen-Ying Zhang, E. Jouanguy, S. Ugolini, A. Smahi, Gaelle Elain, P. Romero, David Segal, V. Sancho-Shimizu, Lazaro Lorenzo, A. Puel and 23 more. Science, 2007

1,116 citations recorded by the source corpus.

Subfields: Epidemiology, Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/93bd7309556bd3694aff2450e2b0d039e4ee5865

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Citations in the corpus

Pathogen Recognition and Inflammatory Signaling in Innate Immune Defenses (2009, background): “nervous system infections with HSV and possibly other neurotropic viruses (400).”
Redefining chronic viral infection. (2009, positive): “virus infection, selectively predispose the host to herpes simplex encephalitis (Casrouge et al., 2006; Zhang et al., 2007).”
Human CD14dim Monocytes Patrol and Sense Nucleic Acids and Viruses via TLR7 and TLR8 Receptors (2010, positive): “Patients unresponsive to TLR3, TLR7, TLR8, and TLR9 (UNC-93B deficiency) share the narrow viral phenotype of TLR3-deficient patients, with herpes simplex encephalitis (Casrouge et al., 2006; Zhang et al., 2007).”
The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors (2010, background): “, and TLR3 deficiency in humans is associated with susceptibility to herpes simplex virus type 1 (HSV-1”
Inborn errors of type I IFN immunity in patients with life-threatening COVID-19 (2020, background): “M. M. Thomsen et al., Identification of an IRF3 variant and defective antiviral interferon responses in a patient with severe influenza.”
Regulation of innate immune responses in the brain (2009, background): “The endosomal TLRs TLR3 and TLR7 have an important role in the expression of innate immune genes in the brains of HSV-infected mic”
Toll-like receptors and their crosstalk with other innate receptors in infection and immunity. (2011, background): “Currently, five PIDs with impaired TLR signaling pathways have been described: autosomal-recessive MyD88, IRAK4, and UNC93B1 deficiency and autosomal-dominant TLR3 and TRAF3 deficiency (Casrouge et al., 2006; Pérez de Diego et al., 2010; Picard et al., 2003; von Bernuth et al., 2008; Zhang et al., 2”
Viral evasion and subversion of pattern-recognition receptor signalling (2008, background): “Evidence for a protective role for TLR3 in natural infections comes from recent studies showing that human patients that bear mutations in TLR3 are predisposed to HSV-associated encephaliti”
Pattern Recognition Receptors and the Innate Immune Response to Viral Infection (2011, background): “Patients with TLR3 dominant negative mutations were found to be more susceptible to herpes simplex encephalitis, a rare but devastating manifestation of HSV-1 infection [32].”