IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors

By K. Honda, Tadatsugu Taniguchi. Nature reviews. Immunology, 2006

1,720 citations recorded by the source corpus.

Subfields: Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/9391f43bc92d3bd391d7ea67e6b0481c9a8321bf

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. R. Randall
2. S. Goodbourn
3. R. Chovatiya
4. Sarah A. Teichmann
5. R. Medzhitov
6. Shizuo Akira
7. Taro Kawai
8. Jonathan C. Kagan

In Oncology

1. R. Randall
2. S. Goodbourn
3. R. Medzhitov
4. Shizuo Akira

Citations in the corpus

• Structural design of engineered costimulation determines tumor rejection kinetics and persistence of CAR T cells (2015, neutral): “In this regard, although we did not see induction of mRNA for IRF3, which encodes the transcription factor that triggers the positive feedback loop of IFN-I induction by activating IFNB1 in virally infected cells (Honda and Taniguchi, 2006), it is known that IRF3 is constitutively expressed; hence, ”
• Stress, Inflammation, and Defense of Homeostasis (2014, background): “A well-known example of this phenomenon is provided by the antiviral defense response: virally infected cells produce type 1 interferons (IFNs) that act on neighboring cells to induce an antiviral state (Honda and Taniguchi, 2006; Levy et al., 2011).”
• Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures. (2008, background): “…form, induction of IFN-b requires the activation of nuclear factor kappa B (NF-kB) and IFN regulatory factor-3 (IRF-3) although, as discussed below, certain other members of the ten-member IRF family (reviewed by Honda & Taniguchi, 2006; Paun & Pitha, 2007) may play a role under some circumstances.”
• A census of human transcription factors: function, expression and evolution (2009, background): “We also emphasize that the success of a particular protein family does not necessarily indicate the importance of individual TFs, and there are many TFs containing unusual DNA-binding domains that are central to human transcriptional regulation (for example, the interferon regulatory famil”
• Immunomodulatory functions of type I interferons (2012, background): “This receptor consists of two subunits — IFNAR1 and IFNAR2 (Ref”