Recognition of a virus-encoded ligand by a natural killer cell activation receptor

By H. Smith, J. Heusel, I. K. Mehta, Sungjin Kim, B. Dorner, O. Naidenko, K. Iizuka, H. Furukawa, D. L. Beckman, J. Pingel and 3 more. Proceedings of the National Academy of Sciences of the United States of America, 2002

836 citations recorded by the source corpus.

Subfields: Epidemiology, Immunology

View Paper: https://www.semanticscholar.org/paper/936d9f653a59637e2ffd2a3e08b7a8128f52bb82

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. A. Varki
2. B. Beutler
3. Shizuo Akira
4. Taro Kawai

In Immunology

1. Shizuo Akira
2. A. Varki
3. B. Beutler
4. K. Hoebe
5. E. Janssen
6. É. Vivier
7. Taro Kawai
8. M. Peterson

Citations in the corpus

• Phospholipase C-γ2 Is a Critical Signaling Mediator for Murine NK Cell Activating Receptors1 (2005, background): “PE-anti-Ly49H (3D10) and FITC-anti-Ly49A (JR9) and FITC-anti-Ly49D (4E4) have been previously described (7, 29).”
• Immune functions encoded by the natural killer gene complex (2003, background): “Recently, the ligand for Ly49h was identified as an MCMV-encoded molecule known as m157, which is expressed with early-phase kinetics in infected cell”
• The Molecular Mechanism of Natural Killer Cells Function and Its Importance in Cancer Immunotherapy (2017, background): “Ly49H binds to the glycoprotein m157 protein of murine cytomegalovirus (MCMV) and imparts resistance to MCMV infection (59).”
• Siglecs and their roles in the immune system (2007, background): “As shown for the NK-cell receptor Ly49H, which binds the MHC-like protein m157 of mouse cytomegaloviru”
• Identification of Lps2 as a key transducer of MyD88-independent TIR signalling (2003, background): “BALB/c mice, which fail to eliminate the virus as a result of a mutation in the NK-activating receptor LY49”
• Controlling NK Cell Responses: Integration of Signals for Activation and Inhibition (2013, background): “Ly49H+ NK cells in C57BL/6 mice are activated by the MCMV-encoded protein m157 expressed on infected cells (35, 37).”
• Functions of natural killer cells (2008, background): “In C57/BL6 mice, NK cells selectively recognize MCMV-infected cells through the interaction between a CMV-encoded cell surface molecule, m157, and the activating NK cell receptor Ly49H (refs”