Patterns of brain activation in people at risk for Alzheimer's disease.

By Susan Y. Bookheimer, M. Strojwas, Mark S. Cohen, A. Saunders, M. Pericak-Vance, John C. Mazziotta, G. Small. New England Journal of Medicine, 2000

1,301 citations recorded by the source corpus.

Subfields: Cognitive Neuroscience, Physiology, Psychiatry and Mental health

View Paper: https://www.semanticscholar.org/paper/934c1a48c39eb93a7340e77de666779fabcd3901

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cognitive Neuroscience

1. Yong He
2. Yufeng Zang
3. Olaf Sporns
4. Randy L. Buckner
5. E. Bullmore
6. Xi-Nian Zuo
7. D. Selkoe
8. Daniel R. Weinberger

In Physiology

1. D. Selkoe
2. Randy L. Buckner
3. G. Shankar
4. D. Walsh
5. Reisa A. Sperling
6. Berislav Zlokovic
7. K. Ashe
8. Vince D. Calhoun

In Psychiatry and Mental health

1. Daniel R. Weinberger
2. D. Selkoe
3. Randy L. Buckner
4. Reisa A. Sperling
5. Venkata S. Mattay
6. Bhaskar S. Kolachana
7. Liang Wang
8. Yufeng Zang

Citations in the corpus

• Impairment and compensation coexist in amnestic MCI default mode network (2010, background): “The compensatory hypothesis is thought to take place in processes of AD, as well as in individuals at risk for AD (Bookheimer et al., 2000).”
• Abnormal Cortical Networks in Mild Cognitive Impairment and Alzheimer's Disease (2010, background): “This compensatory mechanism may play an important role in MCI and AD by enabling patients to use additional cognitive resources to approach a normal level [49–51].”
• Brain imaging in Alzheimer disease. (2012, background): “…al. 2006; Hamalainen et al. 2006; Heun et al. 2007; Kircher et al. 2007; Lenzi et al. 2009), and cognitively intact individuals with genetic risk for AD (Bookheimer et al. 2000; Smith et al. 2002; Wishart et al. 2004; Bondi et al. 2005; Fleisher et al. 2005; Han et al. 2007; Filippini et al. 2009).”
• Brain-Derived Neurotrophic Factor val66met Polymorphism Affects Human Memory-Related Hippocampal Activity and Predicts Memory Performance (2003, background): “More generally, our current findings along with those of other recent studies (Bookheimer et al., 2000; Egan et al., 2001; Hariri et al., 2002), highlight the potential of functional neuroimaging as an approach for exploring the biological impact of genetic variation on information processing within”
• Changes in hippocampal connectivity in the early stages of Alzheimer's disease: Evidence from resting state fMRI (2006, background): “This increased activity (Bookheimer et al., 2000) and connectivity (Grady et al., 2003) has been interpreted to be compensatory recruitment of cognitive resources to maintain task performance in AD patients.”
• Memory and executive function in aging and AD: multiple factors that cause decline and reserve factors that compensate. (2004, background): “W.J. Jagust, C.R. Jack, K. Herholz, W.increased left frontal recruitment relative to control subKlunk, C. Mathis, and J.C. Price generously provided data and im-jects (Bookheimer et al., 2000).”
• High-resolution structural and functional MRI of hippocampal CA3 and dentate gyrus in patients with amnestic mild cognitive impairment (2010, background): “Similar patterns of “hyperactivity” have also been noted in cognitively intact ApoE4 carriers (Bookheimer et al., 2000), in asymptomatic offspring of autopsy-confirmed AD patients (Bassett et al.”