Lysosomal acidification mechanisms.

By Joseph A. Mindell. Annual Review of Physiology, 2012

1,116 citations recorded by the source corpus.

Subfields: Cell Biology, Cellular and Molecular Neuroscience, Physiology

View Paper: https://www.semanticscholar.org/paper/934bda93b8acc54a5b17eb691f753ce0d69f923e

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In Cell Biology

1. N. Mizushima
2. Beth Levine
3. V. Deretic
4. Guido Kroemer
5. I. Slaninová
6. D. Klionsky
7. Douglas R. Green
8. Alec C. Kimmelman

In Cellular and Molecular Neuroscience

1. Beth Levine
2. N. Mizushima
3. M. Jäättelä
4. A. Cuervo
5. Guido Kroemer
6. L. Galluzzi
7. T. Johansen
8. P. Boya

In Physiology

1. Guido Kroemer
2. Beth Levine
3. N. Mizushima
4. Alec C. Kimmelman
5. L. Galluzzi
6. V. Deretic
7. I. Slaninová
8. Douglas R. Green

Citations in the corpus

• The lysosome: from waste bag to potential therapeutic target. (2013, background): “…type C protein; TGN, trans-Golgi network at Shanghai Inform ation C enter for L ife Sciences, C A S on A ugust 12, 2013 http://jm cb.oxfordjournals.org/ D ow nloaded from hydrolysis to pump protons from the cytosol against their electrochemical gradient into the lysosomal lumen (Mindell, 2012).”
• Molecular definitions of autophagy and related processes (2017, positive): “Moreover, amphisomes have been proposed to contain small amounts of the lysosomal V-type ATPase, which would be responsible for progressive acidification of their lumen (Bader et al , 2015).”
• Lysosomal Physiology (2015, background): “ClC transporters and Na+/K+ channels/transporters contribute to acidification by providing counterions (17, 22, 28).”
• Lysosomes as a therapeutic target (2019, background): “Mature lysosomes have an acidic internal pH, at which the lysosomal hydrolases are active, and a lin ing known as a glycocalyx that protects the internal lysosomal perimeter from the acidic environment of the lumen 5, 8, 20 .”
• Lysosomal membrane permeabilization and cell death (2018, background): “ing v-ATPase, chloride channels and ion transporters in the lysosomal membrane.(7) In the ~8 nm lysosomal membrane, the most abundant”
• Lysosomal metabolomics reveals V-ATPase- and mTOR-dependent regulation of amino acid efflux from lysosomes (2017, background): “5 (11), which is thought to be required for the optimal activity of lysosomal hydrolases and to set up a proton gradient with the cytosol that provides energy for transporters to move metabolites across the lysosomal membrane.”