Human pancreatic cancer tumors are nutrient poor and tumor cells actively scavenge extracellular protein.

By Jurre J. Kamphorst, Michel Nofal, Cosimo Commisso, S. Hackett, Wenyun Lu, Elda Grabocka, M. V. Vander Heiden, G. Miller, J. Drebin, D. Bar-Sagi and 2 more. Cancer Research, 2015

754 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/9344491193264f27926e446ad6ad326fd6b01edb

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. M. V. Vander Heiden
2. Ralph J. Deberardinis
3. Alec C. Kimmelman
4. D. Y. Gui
5. Alba Luengo
6. B. Faubert
7. T. Jacks
8. T. Papagiannakopoulos

In Molecular Biology

1. M. V. Vander Heiden
2. Ralph J. Deberardinis
3. D. Y. Gui
4. Alba Luengo
5. Alec C. Kimmelman
6. B. Faubert
7. T. Jacks
8. T. Papagiannakopoulos

In Oncology

1. M. V. Vander Heiden
2. T. Jacks
3. Alec C. Kimmelman
4. Ralph J. Deberardinis

Citations in the corpus

• Environment impacts the metabolic dependencies of Ras-driven non-small cell lung cancer (2016, background): “Nevertheless, the net production of glutamine by lung tumors, despite the availability of this amino acid from the circulation, suggests alternative sources of nitrogen are used, possibly reflecting the propensity of RAS cancers to catabolize extracellular protein (Commisso et al., 2013; Kamphorst e”
• Metabolic reprogramming and cancer progression (2020, background): “The microenvironment can impose a number of non–cell-autonomous pressures on cancer cells, including nutrient and oxygen deprivation, acidification of the extracellular space, and aberrant cell-matrix and cell-cell interactions (2, 49).”
• Metabolic Interactions in the Tumor Microenvironment (2017, background): “Of note, alanine-derived carbon can outcompete glucose and glutamine-derived carbon to fuel metabolism [58], two important biosynthetic substrates that are limiting in the nutrient austere pancreatic TME [62].”
• Understanding the intersections between metabolism and cancer biology (2017, positive): “Pancreatic tumors are particularly oxygen-limited and use yet another strategy, scavenging amino acids from extracellular protein through KRAS-dependent macropinocytosis and circumventing any need to synthesize aspartate from other nutrients (Commisso et al., 2013; Davidson et al., 2016a; Kamphorst ”