Aging and Atherosclerosis: Mechanisms, Functional Consequences, and Potential Therapeutics for Cellular Senescence

By Julie C. Wang, M. Bennett. Circulation Research, 2012

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ROS, Cell Senescence, and Novel Molecular Mechanisms in Aging and Age-Related Diseases (2016, background): “Aged vascular tissues Telomeres length, SA-βGal, p16, and p21 [170, 171]”
Aging and aging-related diseases: from molecular mechanisms to interventions and treatments (2022, background): “Similar to endothelial cell senescence, VSMC senescence also contributes to atherosclerosis.(255) VSMCs coordinate with endothelial cells to control blood pressure, vascular tone, and blood flow.”
Age-Related Diseases and Clinical and Public Health Implications for the 85 Years Old and Over Population (2017, background): “Normal aging includes vascular remodeling and vascular stiffness (21).”
Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice (2016, background): “…et al., 2005), high-fat feeding (Shi et al., 2007), diabetes (Verzola et al., 2008), tobacco exposure (Nyunoya et al., 2006), or atherosclerosis (Wang & Bennett, 2012), and short-term treatment with ‘senolytic’ drugs in chronologically aged or progeroid mice alleviates several aging-related…”