Central and Systemic Endotoxin Challenges Exacerbate the Local Inflammatory Response and Increase Neuronal Death during Chronic Neurodegeneration

By C. Cunningham, D. Wilcockson, Suzanne L. Campion, K. Lunnon, V. Perry. Journal of Neuroscience, 2005

735 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Neurology, Physiology

View Paper: https://www.semanticscholar.org/paper/920216cde3e4cdbcf2ac6658871796e0dcae3d0b

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. M. Block
2. Jau-Shyong Hong
3. C. Cunningham
4. V. Perry
5. T. Wyss‐Coray
6. K. Ressler
7. J. Schwarz
8. S. Bilbo

In Neurology

1. C. Cunningham
2. R. Ransohoff
3. M. Block
4. V. Perry
5. C. Holmes
6. T. Wyss‐Coray
7. Jau-Shyong Hong
8. Paul Edison

In Physiology

1. C. Cunningham
2. R. Ransohoff
3. V. Perry
4. C. Holmes
5. T. Wyss‐Coray
6. M. Block
7. Paul Edison
8. V. Calsolaro

Citations in the corpus

• Immune activation in brain aging and neurodegeneration: too much or too little? (2009, background): “…in mouse models of ALS, optic nerve crush, PD, and prion disease lead to exaggerated CNS inflammation and a significant increase in neurodegeneration, culminating in accelerated disease progression (Cunningham et al., 2005; Frank-Cannon et al., 2008; Nguyen et al., 2004; Palin et al., 2008).”
• Neuroinflammation in Alzheimer's disease: Current evidence and future directions (2016, background): “It has been shown that, in animals with prion disease, microglial cells switch from the anti-inflammatory phenotype to the proinflammatory aggressive one when stimulated with LPS, starting an inflammatory response characterized by increasing IL-1b, TNF, and IL-6 and resulting in behavioral changes, ”
• Microglia-mediated neurotoxicity: uncovering the molecular mechanisms (2007, background): “Recent reports also indicate that systemic and local inflammation induced using LPS in adult mice exacerbates the neuronal damage associated with additional LPS administratio”
• Long-term Air Pollution Exposure Is Associated with Neuroinflammation, an Altered Innate Immune Response, Disruption of the Blood-Brain Barrier, Ultrafine Particulate Deposition, and Accumulation of Amyloid β-42 and α-Synuclein in Children and Young Adults (2008, background): “Systemic and local brain production of cytokines are implicated in contributing to the initiation, propagation, and regulation of immune and inflammatory circuits (Benveniste 1998; Cunningham et al. 2005).”
• Inflammation in Fear- and Anxiety-Based Disorders: PTSD, GAD, and Beyond (2017, background): “Inflammatory processes may have a critical role in the etiology of hippocampal atrophy, as translational work in rodent models indicates that cytokines released from microglia inhibit neurogenesis within the dentate gyrus (Ekdahl et al, 2003) and promote neuronal apoptosis (Cunningham et al, 2005).”
• Early-Life Programming of Later-Life Brain and Behavior: A Critical Role for the Immune System (2009, background): “Supported in part by R01MH083698.”
• Systemic infections and inflammation affect chronic neurodegeneration (2007, background): “We have recently shown that a systemic inflammatory challenge in an animal with a chronic neurodegenerative disease leads to exaggerated brain inflammation, exaggerated sickness behaviour and a significant increase in acute neurodegeneratio”
• Minocycline attenuates lipopolysaccharide (LPS)-induced neuroinflammation, sickness behavior, and anhedonia (2008, background): “Furthermore, we and others have reported that a biological consequence of this reactive glial profile is an exaggerated neuroinflammatory response to innate immune challenge [9,10,12-14,27,28].”