Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease

By J. Hugot, M. Chamaillard, H. Zouali, S. Lesage, J. Cézard, J. Belaiche, S. Almér, C. Tysk, C. O'Morain, M. Gassull and 10 more. Nature, 2001

5,724 citations recorded by the source corpus.

Subfields: Genetics, Immunology, Surgery

View Paper: https://www.semanticscholar.org/paper/91e4a385304126274f4b148a58b806f67d15991c

How researchers see this paper

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In Genetics

1. Matthew Stephens
2. Gonçalo R. Abecasis
3. Jonathan Marchini
4. Mark J. Daly
5. Sharon R. Browning
6. J. K. Pritchard
7. Peter Donnelly
8. Brian L. Browning

In Immunology

1. Shizuo Akira
2. R. Medzhitov
3. Taro Kawai
4. T. Mogensen
5. K. Takeda
6. M. Karin
7. Luke A. O'Neill
8. O. Takeuchi

In Surgery

1. Patrice D Cani
2. Kate Schroder
3. T. Kanneganti
4. F. Ortis
5. Shizuo Akira
6. G. Núñez
7. J. Tschopp
8. Mark J. Daly

Citations in the corpus

• NFκB-dependent signaling pathways (2002, background): “Interestingly, mutations in the NOD 2 gene are linked to susceptibility to Crohn’s inflammatory bowel disease [108–110].”
• The immunological and genetic basis of inflammatory bowel disease (2003, background): “Further analysis of this region identified a strong association with a single gene, NOD2 — also known as caspase-recruitment domain protein 15 ( CARD15”
• Behaviour of Crohn's disease according to the Vienna classification: changing pattern over the course of the disease (2001, background): “Thus apart from specific disease predisposing genes, such as the recently described Nod 2,”
• The Microbiome in Infectious Disease and Inflammation (2012, positive): “NOD2 gene mutations are associated with an increased susceptibility to Crohn’s disease in Western (but not Asian) populations (101, 102).”
• Mechanisms of Disease: pathogenesis of Crohn's disease and ulcerative colitis (2006, background): “The CARD15 gene The first gene to be associated with Crohn's disease was CARD15 (caspase recruitment domain family member 15, formerly known as NOD2 )”
• Alteration of Gut Microbiota in Inflammatory Bowel Disease (IBD): Cause or Consequence? IBD Treatment Targeting the Gut Microbiome (2019, background): “The NOD2 (nucleotide-binding oligomerization domain containing protein 2), a first gene locus, has been reported as a risk locus for Crohn’s disease (CD) [175,176].”
• Intestinal Permeability in Inflammatory Bowel Disease: Pathogenesis, Clinical Evaluation, and Therapy of Leaky Gut (2015, background): “As a matter of fact several defects in bacterial recognition and processing have been documented in CD patients carrying particular genetic polymorphisms, chiefly of pattern-recognition receptors such as NOD2/CARD15 [68, 69] and genes involved in autophagy like ATG16L1 and IRGM [70–72].”