NOX4 activity is determined by mRNA levels and reveals a unique pattern of ROS generation.

By L. Serrander, L. Cartier, K. Bedard, B. Bánfi, B. Lardy, O. Plastre, A. Sienkiewicz, L. Forró, W. Schlegel, K. Krause. Biochemical Journal, 2007

633 citations recorded by the source corpus.

Subfields: Immunology, Physiology

View Paper: https://www.semanticscholar.org/paper/91df547948ed0c9f153830afc341ac65317f2164

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Citations in the corpus

Role of Catalase in Oxidative Stress- and Age-Associated Degenerative Diseases (2019, background): “It causes the generation of hydrogen peroxide instead of other reactive species [84].”
Nox family NADPH oxidases: Molecular mechanisms of activation. (2014, background): “The activity of Nox4 has generally been thought to be constitutive and thus mRNA formation determines ROS production [145], although mRNA stability, translation efficiency, and protein stability of Nox4 are also controlled [146].”
ROS Generation in Microglia: Understanding Oxidative Stress and Inflammation in Neurodegenerative Disease (2020, background): “Since NOX activation relies upon the assembly of multiple subunits, the primary activity regulation is likely dependent on protein kinetics, except for the constitutively active NOX4 which is regulated at the transcriptional level [56,67].”
Reactive Oxygen Species in Inflammation and Tissue Injury (2014, positive): “The type of ROS generated by NOX4-expressing cells is primarily H2O2, whereas O2 - was almost undetectable in these cells (383).”
Combating oxidative stress in vascular disease: NADPH oxidases as therapeutic targets (2011, background): “Instead, the activity of these enzymes results in the direct release of hydrogen peroxid”
Nox proteins in signal transduction (2009, positive): “Signal transduction—Nox4 differs from other Nox enzymes because the O2 produced by Nox4 is rapidly converted to H2O2, so O2 release from this enzyme is almost undetectable [192].”
NOX4 promotes ferroptosis of astrocytes by oxidative stress-induced lipid peroxidation via the impairment of mitochondrial metabolism in Alzheimer's diseases (2021, background): “Since NOX4 is a constitutively active form among the NOX isoforms, the activity of NOX4 depends on its expression [37].”
Diabetes associated cell stress and dysfunction: role of mitochondrial and non‐mitochondrial ROS production and activity (2007, background): “It is thought that cytoplasmic acitivator subunits are not associated with this isoform and H2O2 is the major form of ROS generated by this NOX isoform (Serrander et al. 2007) Thus specific isoforms of the O2− generating NADPH oxidase family (i.”