Reward-related Reversal Learning after Surgical Excisions in Orbito-frontal or Dorsolateral Prefrontal Cortex in Humans

By J. Hornak, John P. O'Doherty, J. Bramham, E. T. Rolls, R. Morris, P. Bullock, C. Polkey. Journal of Cognitive Neuroscience, 2004

638 citations recorded by the source corpus.

Subfields: Cognitive Neuroscience

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Citations in the corpus

Neurophysiology of performance monitoring and adaptive behavior. (2014, background): “This is particularly evident in studies using reversal learning (172, 261, 272, 274, 285, 351, 442) or reinforcer devaluation (25, 414, 415), or during extinction of a previously acquired instrumental response (65, 442).”
Synaptic and spiking dynamics underlying reward reversal in the orbitofrontal cortex. (2004, background): “one-trial, stimulus--reward switching, the orbitofrontal cortex (Thorpe et al., 1983; Rolls et al., 1994, 1996; Hornak et al., 2004; Rolls, 2004a).”
The functional neuroanatomy of the human orbitofrontal cortex: evidence from neuroimaging and neuropsychology. (2004, methodology): “Further support for this medial–lateral distinction comes from a recent neuropsychological study using patients with circumscribed surgical lesions (Hornak et al., 2004).”
Probing Compulsive and Impulsive Behaviors, from Animal Models to Endophenotypes: A Narrative Review (2010, background): “are functionally separate and reciprocally yoked, lending support to the impulsive–compulsive diathesis model ( Hollander and Wong, 1995 ).”
The orbitofrontal cortex and beyond: from affect to decision-making. (2008, background): “These emotional changes may be related at least in part to a failure to rapidly update the reinforcement associations of stimuli when the contingencies are changed as in a visual discrimination reversal task (Fellows and Farah, 2003; Hornak et al., 2004; Rolls, 1999b, 2005; Rolls et al., 1994).”
The neural architecture of emotion regulation (2007, result): “Consistent with these findings, neuropsychological studies have shown impairments of stimulus-reinforcer reversal learning in patients with lesions of ventral and orbital but not dorsolateral PFC (Fellows & Farah, 2003, 2004; Hornak et al., 2004).”
The Neural Bases of Distraction and Reappraisal (2010, neutral): “, 1999), vlPFC regions that may reflect a stimulusʼs current affective value (Bender, Hellwig, Resch, & Weisbrod, 2007; Boettiger & DʼEsposito, 2005; Hornak et al., 2004), and inferior temporal regions important for recognizing social cues (Britton et al.”
Depression, Stress, and Anhedonia: Toward a Synthesis and Integrated Model (2014, background): “Consistent with this view, OFC lesions in humans lead to perseverative responses in reversal-learning tasks (e.g., Hornak et al. 2004), and neuroimaging studies have shown that the OFC codes incentive, rather than sensory, features of stimuli across modalities (O’Doherty 2004).”
Changes in emotion after circumscribed surgical lesions of the orbitofrontal and cingulate cortices. (2003, background): “It was also found that the patients with bilateral OFC damage were as a group impaired at visual discrimination reversal (Hornak et al., 2003), a measure that re ̄ects ̄exible stimulus±reinforcement association learning, itself an important aspect of emotion (Rolls, 1999a).”