Depression, Stress, and Anhedonia: Toward a Synthesis and Integrated Model
By Diego A. Pizzagalli. Annual Review of Clinical Psychology, 2014
1,087 citations recorded by the source corpus.
Depression is a significant public health problem, but its etiology and pathophysiology remain poorly understood. Such incomplete understanding likely arises from the fact that depression encompasses a heterogeneous set of disorders. To overcome these limitations, renewed interest in intermediate phenotypes (endophenotypes) has resurfaced, and anhedonia has emerged as one of the most promising endophenotypes of depression. Here, a heuristic model is presented postulating that anhedonia arises from dysfunctional interactions between stress and brain reward systems. To this end, we review and integrate three bodies of independent literature investigating the role of (1) anhedonia, (2) dopamine, and (3) stress in depression. In a fourth section, we summarize animal data indicating that stress negatively affect mesocorticolimbic dopaminergic pathways critically implicated in incentive motivation and reinforcement learning. In the last section, we provide a synthesis of these four literatures, present initial evidence consistent with our model, and discuss directions for future research.
Subfields: Cardiology and Cardiovascular Medicine, Cellular and Molecular Neuroscience, Experimental and Cognitive Psychology
View Paper: https://www.semanticscholar.org/paper/e094ba01e609a45d4b08e429243d71c8ed0b3a7a
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In Experimental and Cognitive Psychology
Citations in the corpus
- Burnout: Moving beyond the status quo. (2017, background): “As underlined by Pizzagalli (2014), although severe stressors have been generally linked to increased risk of depression, chronic stressors and events characterized by perceived (a) lack of control, (b) inability to escape or resolve the aversive situation (e.g., entrapment), or (c) loss of status…”