An evolutionarily conserved function of the Drosophila insulin receptor and insulin-like peptides in growth control.

By Walter Brogiolo, Hugo Stocker, Tomoatsu Ikeya, F. Rintelen, R. Fernandez, E. Hafen. Current Biology, 2001

1,224 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/91922c9fa458ef35c980e855142536bf98c18afc

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. Jae H. Park
2. G. Davidowitz
3. Gyunghee G. Lee
4. R. Tjian
5. D. Kodrík

In Immunology

1. Bruce Edgar

In Molecular Biology

1. Stephen M Cohen
2. A. Crean
3. G. Davidowitz
4. R. Tjian
5. R. Bonduriansky
6. Alexander T. Sentinella
7. David P. Bartel
8. C. Alberini

Citations in the corpus

• Drosophila's insulin/PI3-kinase pathway coordinates cellular metabolism with nutritional conditions. (2002, background): “One possibility is that activation of PI3Kdilps are expressed in the salivary glands, imaginal causes the larva to perceive that it is well fed and sati-discs, and small numbers of cells in the central nervous system (Brogiolo et al., 2001).”
• Control of cell number by Drosophila FOXO: downstream and feedback regulation of the insulin receptor pathway. (2003, background): “Flies with heteroallelic combinations of dInR mutations are reduced in size because of fewer and smaller cells (Fernandez et al. 1995; Chen et al. 1996; Brogiolo et al. 2001).”
• 1.3 – Vitellogenesis and Post-Vitellogenic Maturation of the Insect Ovarian Follicle (2005, background): “The expression levels of DILPs in the brain respond to variations in nutrition, and overexpression of DILP2 results in an increase in body weight and organismal size (Brogiolo et al., 2001).”
• The effects of environmental variation on a mechanism that controls insect body size (2004, background): “The time required to eliminate traces of juvenile hormone is determined in part by the activity of juvenile hormone esterase (Browder et al., 2001).”
• Insulin receptor isoforms and insulin receptor/insulin-like growth factor receptor hybrids in physiology and disease. (2009, background): “forapartial loss-of-functionmutation inDrosophila IR(25).”
• Dietary protein mediates a trade-off between larval survival and the development of male secondary sexual traits (2013, background): “…animal taxa, this metabolic signalling pathway regulates the rate of somatic tissue growth by linking the availability of dietary nutrients to cell growth and proliferation (Britton & Edgar 1998; Brogiolo et al. 2001; Britton et al. 2002; Ikeya et al. 2002; Teleman 2009; Tennessen & Thummel 2011).”
• Hemolymph Sugar Homeostasis and Starvation-Induced Hyperactivity Affected by Genetic Manipulations of the Adipokinetic Hormone-Encoding Gene in Drosophila melanogaster (2004, methodology): “Ectopic expression of rpr in various peptidergic neurons has been successfully employed to trigger the apoptosis of these neurons (McNabb et al. 1997; Renn et al. 1999; Park et al. 2003).”