Breast cancer stem cells are regulated by mesenchymal stem cells through cytokine networks
By Suling Liu, Christophe Ginestier, S. J. Ou, Shawn G. Clouthier, Shivani H. Patel, F. Monville, H. Korkaya, Amber Heath, J. Dutcher, C. Kleer and 4 more. Cancer Research, 2011
614 citations recorded by the source corpus.
We have utilized in vitro and mouse xenograft models to examine the interaction between breast cancer stem cells (CSCs) and bone marrow derived mesenchymal stem cells (MSCs). We demonstrate that both of these cell populations are organized in a cellular hierarchy in which primitive aldehyde dehydrogenase (ALDH) expressing mesenchymal cells regulate breast CSCs through cytokine loops involving IL6 and CXCL7. In NOD/SCID mice, labeled MSCs introduced into the tibia traffic to sites of growing breast tumor xenografts where they accelerate tumor growth by increasing the breast cancer stem cell population. Utilizing immunochemistry, we identified “MSC-CSC niches” in these tumor xenografts as well as in frozen sections from primary human breast cancers. Bone marrow derived mesenchymal stem cell may accelerate human breast tumor growth by generating cytokine networks that regulate the cancer stem cell population.
Subfields: Genetics, Oncology, Psychiatry and Mental health
View Paper: https://www.semanticscholar.org/paper/6b0e86fa3c36d80539deff3fb3b3dae9a725b968
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Citations in the corpus
- Accessories to the crime: functions of cells recruited to the tumor microenvironment. (2012, positive): “…Psaila and Lyden, 2009), and (2) the myofibroblastic/MSC subtype of CAFs, likely also present in metastatic vascular stem cell niches (Kidd et al., 2009; Korkaya et al., 2011; Liu et al., 2011; Spaeth et al., 2008, 2009); similar niche-forming cells may also nurture CSCs inside primary tumors.”
- Tumor-Associated Macrophages Produce Interleukin 6 and Signal via STAT3 to Promote Expansion of Human Hepatocellular Carcinoma Stem Cells (2014, background): “CSC properties can be promoted by microenvironmental factors.(8,9,21) To determine the relationship between CSCs and TAMs, freshly digested HCC patient tumor cells underwent flow cytometry.”
- The Cancer Stem Cell Niche: How Essential is the Niche in Regulating Stemness of Tumor Cells? (2015, neutral): “Breast CSCs can produce IL6, which attracts and activates MSCs to produce the CSC-supportive cytokine CXCL7 (Liu et al., 2011).”