A regulatory B cell subset with a unique CD1dhiCD5+ phenotype controls T cell-dependent inflammatory responses.

By K. Yanaba, J. Bouaziz, K. Haas, J. Poe, M. Fujimoto, T. Tedder. Immunity, 2008

1,279 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/103f6d5d096331394353d851af59bb0f22081941

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Citations in the corpus

Regulatory B cells: origin, phenotype, and function. (2015, neutral): “, 2014b), CD5CD1d B (B10) cells (Yanaba et al., 2008; Yoshizaki et al., 2012), marginal-zone (MZ) B cells (Gray et al.”
CD19(+)CD24(hi)CD38(hi) B cells exhibit regulatory capacity in healthy individuals but are functionally impaired in systemic Lupus Erythematosus patients. (2010, methodology): “Different B cell subsets have been ascribed with regulatory function, such as CD5+B-1a cells (Carroll and Prodeus, 1998; Silverman et al., 2008), CD19hiCD1dhiCD5+ B cells (Matsushita et al., 2008; Yanaba et al., 2008a), or marginal zone (MZ) B cells (Gray et al., 2007; Lenert et al., 2005).”
B cell depletion therapy ameliorates autoimmune disease through ablation of IL-6–producing B cells (2012, background): “The so-called B reg cells identified by some groups (e.g., B10 cells [Yanaba et al., 2008] or TN B cells [Blair et al., 2010]) may simply represent the most active IL-10 producers ex vivo; however, under stimulatory or inflammatory conditions other cells may come into play in vivo (e.g., MZ B…”
Regulatory B cells inhibit EAE initiation in mice while other B cells promote disease progression. (2008, background): “IL-10–produced by B cells can also down-regulate other autoimmune and inflammatory diseases such as collagen-induced arthritis, inflammatory bowel disease, and contact hypersensitivity (17, 41, 42).”
The double life of a B-1 cell: self-reactivity selects for protective effector functions (2011, background): “The relationship between the recently identified interleukin-10 (IL-10)-producing regulatory B cell populatio”
Effector and regulatory B cells: modulators of CD4+ T cell immunity (2010, background): “Finally, regulatory B cells (also referred to as B10 cells by Tedder and colleague”