Impaired Thermosensation in Mice Lacking TRPV3, a Heat and Camphor Sensor in the Skin

By A. Moqrich, S. Hwang, Taryn J. Earley, Matt J. Petrus, Amber N. Murray, Kathryn S. Spencer, M. Andahazy, G. M. Story, Ardem Patapoutian. Science, 2005

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Environmental temperature is thought to be directly sensed by neurons through their projections in the skin. A subset of the mammalian transient receptor potential (TRP) family of ion channels has been implicated in this process. These “thermoTRPs” are activated at distinct temperature thresholds and are typically expressed in sensory neurons. TRPV3 is activated by heat (>33°C) and, unlike most thermoTRPs, is expressed in mouse keratinocytes. We found that TRPV3 null mice have strong deficits in responses to innocuous and noxious heat but not in other sensory modalities; hence, TRPV3 has a specific role in thermosensation. The natural compound camphor, which modulates sensations of warmth in humans, proved to be a specific activator of TRPV3. Camphor activated cultured primary keratinocytes but not sensory neurons, and this activity was abolished in TRPV3 null mice. Therefore, heat-activated receptors in keratinocytes are important for mammalian thermosensation.

Subfields: Cellular and Molecular Neuroscience, Nutrition and Dietetics, Sensory Systems

View Paper: https://www.semanticscholar.org/paper/90efa7f30070155d23862ce24fc0eea020eeec06

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Citations in the corpus

Trp ion channels and temperature sensation. (2006, methodology): “Moqrich et al. (2005) have reported that thermotaxis is impaired in TRPV3−/− mice.”
An introduction to TRP channels. (2006, background): “Although thermosensitive TRPV channels do appear to function in thermosensation (67, 68), these channels are also expressed in tissues in which thermoregulatory homeostasis should preclude dramatic temperature swings.”
Methods Used to Evaluate Pain Behaviors in Rodents (2017, background): “place preference test and can be used to assess both cold or heat avoidance or preference (Moqrich et al., 2005).”
TRPM8 is required for cold sensation in mice. (2007, neutral): “of mice lacking TRPM8 and TRPV3/4 could address the overlapping role of heat- and cold-activated ion channels in innocuous thermosensation (Lee et al., 2005; Moqrich et al., 2005 ).”
Temperature Monitoring and Perioperative Thermoregulation (2008, background): “TRPV1 4 receptors are heat activated, whereas TRPM8 and TRPA1 are activated by cold.(70,71) Most ascending thermal information traverses the spinothalamic tracts in the anterior spinal cord, but no single spinal tract is critical for conveying thermal information.”
The transient receptor potential family of ion channels (2011, background): “The classic example is heatsensitive TRPV1, which is activated by structurally unrelated botanical compounds such as capsaicin (the pungent extract of hot peppers [78]), resiniferatoxin (an active compound from the cactus Euphorbia resinifera [79]), piperine (the pungent component in black pepper [”