ICOS is critical for CD40-mediated antibody class switching

By A. McAdam, R. Greenwald, M. Levin, T. Chernova, Nelly Malenkovich, V. Ling, G. Freeman, Arlene H. Sharpe. Nature, 2001

745 citations recorded by the source corpus.

Subfields: Immunology, Oncology, Radiology, Nuclear Medicine and Imaging

View Paper: https://www.semanticscholar.org/paper/9058a7715ec14c0e56403e947f6404e98579e9b8

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Citations in the corpus

• Of Mice and Not Men: Differences between Mouse and Human Immunology (2004, background): “Whereas in mice the loss of ICOS does not affect either the number of mature B cells, their maturation status or their secretion of IgM (55, 56), the loss of ICOS in humans results in a severe reduction in B cell number, maturation status and secretion of IgM (57).”
• FOLLICULAR HELPER T CELLS: LINEAGE AND LOCATION (2009, background): “ICOS-deficient humans and mice (Dong et al., 2001; McAdam et al., 2001; Tafuri et al., 2001) and ICOS-L-deficient mice have marked deficits in antibody production, isotype switch, and GC formation.”