Efficient generation of retinal progenitor cells from human embryonic stem cells

By D. Lamba, M. Karl, C. Ware, T. Reh. Proceedings of the National Academy of Sciences of the United States of America, 2006

675 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/90393f1e7b12bce6d49a47c5eca3b0c895e4be2a

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In Cellular and Molecular Neuroscience

In Molecular Biology

Citations in the corpus

Differentiation of embryonic stem cells to clinically relevant populations: lessons from embryonic development. (2008, background): “Many signaling pathways known to regulate neural cell fate in the embryo have been exploited to control neural differentiation from ESCs, including Notch (reviewed in Androutsellis-Theotokis et al., 2006; Hitoshi et al., 2002; Lowell et al., 2006), sonic hedgehog (Maye et al., 2004), Wnts (Davidson ”
Self-formation of optic cups and storable stratified neural retina from human ESCs. (2012, background): “…including photoreceptors and retinal pigment epithelium, from pluripotent stem cells (Boucherie et al., 2011; Lund et al., 2006; Lu et al., 2009a; Meyer et al., 2011; Osakada et al., 2008; Idelson et al., 2009; Lamba et al., 2006, 2010; Carr et al., 2009; Ikeda et al., 2005; Kawasaki et al., 2002).”
Transplantation of human embryonic stem cells derived photoreceptors restores some visual function in Crx deficient mice (2009, positive): “We have previously shown that human ESCs can be directed to a retinal cell fate using a combination of a BMP inhibitor, a Wnt inhibitor, and IGF-1 (Lamba et al., 2006).”
Organogenesis in a dish: Modeling development and disease using organoid technologies (2014, background): “Skeletal muscle Embryonic chick leg skeletal muscle (76) Mesoangioblasts from human iPSCs (106) Anchored contracting skeletal muscle in 3D matrix derived from myoblast progenitors (107) Bone Skeletal bone of chick embryonic leg (77) Osteoblasts from mESCs (108) and hESCs (109) Bone spheroids from hu”
Modeling early retinal development with human embryonic and induced pluripotent stem cells (2009, background): “To date, hESC studies have focused on the derivation of subsets of retinal cell populations, with emphasis on the production of either retinal progenitors (5, 6) or more mature cells such as retinal pigment epithelium (RPE) (3, 4) or photoreceptors (7).”