Transplantation of human embryonic stem cells derived photoreceptors restores some visual function in Crx deficient mice
By D. Lamba, Jule Gust, T. Reh. Cell Stem Cell, 2009
625 citations recorded by the source corpus.
Summary Some of the most common causes of blindness involve the degeneration of photoreceptors in the neural retina; photoreceptor replacement therapy might restore some vision in these individuals. Embryonic stem (ES) cells could in principle provide a source of photoreceptors to repair the retina. We have previously shown that retinal progenitors can be efficiently derived from human ES cells. We now show that retinal cells derived from human ES cells will migrate into mouse retinas following intra-ocular injection, settle into the appropriate layers and express markers for differentiated cells, including both rod and cone photoreceptor cells. After transplantation of the cells into the subretinal space of adult Crx -/- mice (a model of Leber's Congenital Amaurosis), the hES cell derived retinal cells differentiate into functional photoreceptors and restore light responses to the animals. These results demonstrate that hES cells can, in principle, be used for photoreceptor replacement therapies.
Subfields: Cellular and Molecular Neuroscience, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/1c78d6b86bc2c723195de63a3f228bb7b25ca4e2
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Citations in the corpus
- Modeling early retinal development with human embryonic and induced pluripotent stem cells (2009, result): “(33) noted similar results using a mixture of retinal cell types derived from hESCs.”
- A fresh look at iPS cells. (2009, background): “The therapeutic effects of human ES cellderived progeny have been reported in animal models of spinal cord injury (Keirstead et al., 2005), retinal disease (Lamba et al., 2009), and Parkinson’s disease (Yang et al., 2008).”