SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex

By F. Tokunaga, T. Nakagawa, Masaki Nakahara, Y. Saeki, M. Taniguchi, Shin-ichi Sakata, Keiji Tanaka, H. Nakano, K. Iwai. Nature, 2011

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Targeting IAP proteins for therapeutic intervention in cancer (2012, background): “In coordination with haem-oxidized IRP2 ubiquitin ligase 1 (HOIL1; also known as RBCK1) and Sharpin, HOIP promotes the assembly of linear ubiquitin chains on NEMO and RIP1, and stabilizes the signalling complexe”
ZBP1 and TAK1: Master Regulators of NLRP3 Inflammasome/Pyroptosis, Apoptosis, and Necroptosis (PAN-optosis) (2019, background): “Similarly, genetic deficiency of the NF-κB and MAPK components suggests a role for the necrosome components RIPK1 and RIPK3 in promoting NLRP3 inflammasome activation, triggering multiple forms of cell death and the development of inflammatory diseases (Ikeda et al., 2011; Matmati et al., 2011; Toku”
A Proteome-wide, Quantitative Survey of In Vivo Ubiquitylation Sites Reveals Widespread Regulatory Roles (2011, background): “ubiquitin chain assembly complex (47, 48), which has an important role in the activation of NF- B downstream of these”
Signaling in innate immunity and inflammation. (2012, background): “Recruitment of LUBAC components sharpin, HOIL-1, and HOIP to the TNF-RI complex is linked to cIAP ubiquitin ligase activity, and linear ubiquitylation of RIP1 and NEMO may stabilize the TNF-RI signaling complex (Haas et al. 2009; Gerlach et al. 2011; Ikeda et al. 2011; Tokunaga et al. 2011).”