Yersinia YopJ Acetylates and Inhibits Kinase Activation by Blocking Phosphorylation

By S. Mukherjee, Gladys J. Keitany, Yan Li, Yong Wang, H. Ball, E. Goldsmith, K. Orth. Science, 2006

645 citations recorded by the source corpus.

Subfields: Genetics, Pharmacology

View Paper: https://www.semanticscholar.org/paper/8ee4f47aefd74e39cb9a26945f3e16347e39b863

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In Genetics

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4. T. Kanneganti
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Citations in the corpus

• Caspases in Cell Death, Inflammation, and Gasdermin-Induced Pyroptosis (2020, background): “YopJ, an effector protein of Yersinia, inhibits TAK1 function, inducing cell death in macrophages (168, 169).”
• HATs and HDACs: from structure, function and regulation to novel strategies for therapy and prevention (2007, background): “Protein O-acetylation has just been discovered and directly competes with phosphorylation (Mittal et al., 2006; Mukherjee et al., 2006).”
• ZBP1 and TAK1: Master Regulators of NLRP3 Inflammasome/Pyroptosis, Apoptosis, and Necroptosis (PAN-optosis) (2019, background): “, the NF-κB and MAPK pathways) and initiate the assembly of multifaceted cell death complexes to drive PAN-optosis to promote inflammation, immune responses, and protection against infection (Mukherjee et al., 2006; Paquette et al., 2012; Philip et al., 2014; Weng et al., 2014; Orning et al., 2018; ”
• Triterpenoids and rexinoids as multifunctional agents for the prevention and treatment of cancer (2007, background): “, SO could potentially interact with nucleophilic groups on lysine, arginine or histidine on target proteins, or alter post-translational modifications including acetylatio”
• Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer (2007, background): “YopJ functions as an acetyltransferase, using acetyl-coenzyme A (CoA) to modify the critical serine and threonine residues in the activation loop of MEKs and thereby blocking MAPKKK phosphorylation and activation (Mukherjee et al., 2006).”
• The age of crosstalk: phosphorylation, ubiquitination, and beyond. (2007, background): “Stoichiometric acetylation of the two MAP2K activation loop Ser by YopJ, which is encoded by the virulence plasmid of Yersinia pestis, blocks phosphorylation by upstream MAP3Ks and is used by the bacterium to shut down MAPK signaling globally in the infected cell ( Mukherjee et al., 2006 ).”
• Differential regulation and properties of MAPKs (2007, background): “The elucidation of the mechanism of YopJ action revealed a novel covalent modification in mammalian cells (Mukherjee et al., 2006).”