Neurodegenerative tauopathies.

By V. Lee, M. Goedert, John Q. Trojanowski. Annual Review of Neuroscience, 2001

2,045 citations recorded by the source corpus.

Subfields: Neurology, Physiology, Psychiatry and Mental health

View Paper: https://www.semanticscholar.org/paper/8eb6355272daf41b8da72a5b18a4d8c67d8509cc

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Citations in the corpus

Alzheimer’s Disease and the β-Amyloid Peptide (2010, neutral): “The neuroﬁbrillary tangles in the different diseases have some distinctive morphological features and may exhibit a distinct composition of tau isoforms that differs from AD [1].”
Clinical Neurology and Epidemiology of the Major Neurodegenerative Diseases. (2018, background): “…with atrophy within the basal ganglia, subthalamus, and brainstem, and is characterized microscopically by dense fibrillary four-repeat tau (4R tauopathy) filaments, globose-appearing neurofibrillary tangles, and glial fibrillary tangles in astrocytes and oligodendrocytes (Lee et al. 2001).”
GABAergic Interneuron Dysfunction Impairs Hippocampal Neurogenesis in Adult Apolipoprotein E4 Knock-in Mice (2009, background): “The major function of tau, which is abundant in the axons of neurons, is to bind and stabilize microtubules (Lee et al., 2001).”
Abundant Tau Filaments and Nonapoptotic Neurodegeneration in Transgenic Mice Expressing Human P301S Tau Protein (2002, background): “In FTDP-17, the age of onset of disease varies, depending on the Tau mutation.”
Inflammatory processes in Alzheimer's disease. (2007, positive): “AD brains show two characteristic lesions: extracellular deposits of β-amyloid peptides, so-called neuritic or senile plaques, and intracellular neurofibrillary tangles of hyperphosphorylated tau (Lee et al., 2001; Selkoe, 2003).”
Molecular mechanisms of neurodegeneration in Alzheimer's disease. (2010, background): “This is accompanied by astrogliosis (9), microglial cell proliferation (10, 11) and the presence of neurofibrillary tangles composed of dystrophic neurites and hyperphosphorylated tau (5, 12-16).”
Tau fragmentation, aggregation and clearance: the dual role of lysosomal processing. (2009, background): “Abnormal aggregates of Tau [neurofibrillary tangles, consisting of paired helical filaments (PHFs)] are hallmarks of several neurodegenerative diseases including Alzheimer disease (AD) and other tauopathies (1,2).”
Role of tau protein in both physiological and pathological conditions. (2004, background): “Several good reviews dealing with specific features of tau have been published recently (32, 147, 160, 182, 254).”
Reconsideration of Amyloid Hypothesis and Tau Hypothesis in Alzheimer's Disease (2018, background): “Tau pathologies are also seen in other neurodegenerative dementing disorders, such as frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17), Pick’s disease (PiD), progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), argyrophilic grain disease (AGD), tangleonly ”