Glutathione metabolism in brain

By R. Dringen, J. M. Gutterer, J. Hirrlinger. 2000

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Role of Free Radicals in the Neurodegenerative Diseases (2001, background): “[185] In general, glial cells appear less susceptible to reactive species (including ONOO–) than do neurons[186] and glia may be able to quickly upregulate the synthesis of GSH.”
Glutathione, oxidative stress and neurodegeneration. (2000, background): “Reasons may include glial production of NO and cytokines [30] or an insufficient supply of GSH precursors to neurons by astrocytes [ 1 ].”
Selective Neuronal Vulnerability to Oxidative Stress in the Brain (2010, positive): “…important roles in maintaining overall CNS homeostasis, providing trophic support to neurons, clearing synapses of the released neurotransmitters, reestablishing ionic gradients near the synapse, mediating immune responses in the brain, and reducing OS (Dringen et al., 2000; Park et al., 2001).”
Coordinate Regulation of Glutathione Biosynthesis and Release by Nrf2-Expressing Glia Potently Protects Neurons from Oxidative Stress (2003, background): “One mechanism underlying this protection is the continuous glial delivery of GSH and/or GSH precursors to neurons for GSH synthesis (Yudkoff et al., 1990; Sagara et al., 1993a,b; Dringen et al., 1999, 2000 ).”