Glutathione, oxidative stress and neurodegeneration.

By J. Schulz, Jörg Lindenau, J. Seyfried, J. Dichgans. European Journal of Biochemistry, 2000

1,232 citations recorded by the source corpus.

Subfields: Biochemistry, Biological Psychiatry, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/3dcf5659732cff793e1dbc70ec429781adfe749e

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biochemistry

1. A. Holmgren
2. V. Lushchak

In Molecular Biology

1. A. Holmgren
2. V. Lushchak
3. P. Brundin
4. H. Sies

Citations in the corpus

• Metabolic endophenotype and related genotypes are associated with oxidative stress in children with autism (2006, methodology): “We have used a targeted approach to ‘‘metabolomics’’ by focusing on the dynamics of a single metabolic pathway involving methionine transmethylation and transsulfuration that has been implicated in the pathogenesis of numerous other neurologic disorders [Schulz et al., 2000; Pogribna et al., 2001; S”
• The Cystine/Glutamate Antiporter System xc − in Health and Disease: From Molecular Mechanisms to Novel Therapeutic Opportunities (2013, neutral): “Cells contain not only small-molecule antioxidants such as vitamins C and E and the tripeptide glutathione (GSH), which scavenge the ROS produced during the cell’s metabolism, but also enzymes whose specific role is the neutralization of ROS [reviewed in (241)].”
• Pathogenesis of parkinson's disease: dopamine, vesicles and α-synuclein (2002, background): “cgi?Q=gpx*[sym]%20not%20pseudogene&ORG=Hs">glutathione peroxidase , is also markedly decreased in the substantia nigr”
• Molecular and Structural Basis for Redox Regulation of β-Actin (2007, background): “This view is further strengthened by observations that a perturbed oxidative balance with increased ROS levels seems to be symptomatic of a number of disease types as well as cellular senescence.(77,78) Overoxidation may have severe consequences, as oxidative damage is surmised to occur in neurodege”
• Glutathione Homeostasis and Functions: Potential Targets for Medical Interventions (2012, background): “This provides the basis for recycling of excreted GSH and GSSG (salvage cycle) by the cell of origin or by other cells [34].”
• Immunomodulatory and therapeutic properties of the Nigella sativa L. seed. (2005, background): “The cause of this oxidative damage has been reported to be due to the shift in the balance of the pro-oxidant (free radicals) and the anti-oxidant (scavenging) mediators, where pro-oxidant conditions dominate either due to the increased generation of the free radicals caused by excessive oxidative s”