The worldwide emergence of plasmid-mediated quinolone resistance.

By Ari Robicsek, G. Jacoby, D. Hooper. Lancet. Infectious Diseases (Print), 2006

948 citations recorded by the source corpus.

Subfields: Epidemiology, Molecular Medicine

View Paper: https://www.semanticscholar.org/paper/8e955a92649ceadab328ecca6a0e8bf44fc6432e

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. H. Nikaido
2. Ole Lund
3. D. Hooper
4. Ari Robicsek
5. P. Mullany
6. H. Aarts
7. A. Roberts
8. B. Guerra

In Molecular Medicine

1. P. Nordmann
2. L. Poirel
3. H. Nikaido
4. Xian-Zhi Li
5. G. Jacoby
6. David L. Paterson
7. D. Hooper
8. Ari Robicsek

Citations in the corpus

• Guidelines for Preventing Infectious Complications among Hematopoietic Cell Transplant Recipients: A Global Perspective (2009, background): “Local epidemiological data should be carefully considered before applying fluoroquinolone prophylaxis, and once it is applied, the emergence of resistance in bacterial pathogens should be monitored closely because of increasing quinolone resistance worldwide among Gram-negative bacteria (eg, Escheri”
• Multidrug Resistance in Bacteria (2009, background): “Plasmid-coded Qnr proteins, which have become more prevalent in recent years, are thought to protect DNA topoisomerases from (fluoro)quinolones (22).”
• Multiplex PCR for detection of plasmid-mediated quinolone resistance qnr genes in ESBL-producing enterobacterial isolates. (2007, background): “Only QnrB determinants were identified from that collection from Kuwait, whereas QnrA has been reported worldwide.(2) Both E.”
• ResFinder 4.0 for predictions of phenotypes from genotypes (2020, background): “For example, only specific mutations in aac(6 0 )-Ib mediate fluoroquinolone resistance in E. coli and Salmonella , 29 which explains why aac(6’)-Ib-cr with 100% identity to the database entry is detected in ciprofloxacin WT Salmonella spp. isolates (Table S5).”
• Plasmid-Mediated Quinolone Resistance: a Multifaceted Threat (2009, background): “For example, qnrA1 plasmids can vary in size from 20 to 320 kb (17, 112) and belong to at least three plasmid incompatibility (Inc) groups (157). qnrA1 is usually associated with ISCR1 (formerly orf513) (193), although 6.2% of qnrA1-positive strains in a study from South Korea were negative for ISCR”
• Efflux-Mediated Drug Resistance in Bacteria: an Update (2009, background): “[222,326] Over the past decade, qnr-containing plasmids have become widespread among fluoroquinoloneresistant bacteria including Klebsiella.”
• Antimicrobial Resistance in ESKAPE Pathogens (2020, background): “PMQR is common among ESBL-producing organisms and can augment fluoroquinolone resistance levels arising through other mechanisms (194, 195).”
• Acquired Antibiotic Resistance Genes: An Overview (2011, background): “Resistance mechanism For decades, the mechanisms of resistance to quinolones were believed to be only chromosome-encoded, however, recently three plasmid-mediated resistance mechanisms have been reported (Robicsek et al., 2006a; Courvalin, 2008; Martínez-Martínez et al., 2008).”