Control of mitochondrial apoptosis by the Bcl-2 family

By J. Brunelle, A. Letai. Journal of Cell Science, 2009

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Apoptosis as anticancer mechanism: function and dysfunction of its modulators and targeted therapeutic strategies (2016, background): “The pro-apoptotic BH3-only proteins act upstream of this event binding with high affinity to anti-apoptotic Bcl-2 family members thereby allowing Bax/Bak to elicit MOMP and activation of the caspase cascade [36,37].”
Anti-apoptosis and cell survival: a review. (2011, background): “An up-regulation of autophagy is also unlikely to be responsible for the antagonist effects of other anti-apoptotic processes such as the ability of Bcl2 to directly interfere with the pro-apoptotic function of activated Bax [10].”
Role of Bcl-2 family proteins and caspases in the regulation of apoptosis (2011, background): “Following death signal, BH3 domain-only proteins also known as minimal death domain can neutralize or depress antiapoptotic Bcl-2 proteins allowing pro-apoptotic proteins such as Bax/Bak-like proteins to induce apoptosis [39, 40].”