Identification of the haemoglobin scavenger receptor

By M. Kristiansen, J. Graversen, C. Jacobsen, O. Sonne, H. Hoffman, S. Law, S. Moestrup. Nature, 2001

1,742 citations recorded by the source corpus.

Subfields: Cell Biology, Genetics, Pediatrics, Perinatology and Child Health

View Paper: https://www.semanticscholar.org/paper/8e1d1429e2859503c8ba501110bf1a4210e355e6

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In Genetics

In Pediatrics, Perinatology and Child Health

Citations in the corpus

Systemic iron homeostasis. (2013, background): “In addition to carriers that bind inorganic iron, hemopexin and haptoglobin are plasma proteins that bind free heme and free hemoglobin, respectively, limiting their toxic effects and scavenging them for recycling into iron (116, 133, 245).”
Role of Kupffer cells in host defense and liver disease (2006, background): “In addition KC express the scavenger receptor CD163, which has been involved in clearance and endocytosis of hemoglobin–haptoglobin complexes thereby protecting tissues from free haemoglobin-mediated oxidant injury (25).”
Ischemia/Reperfusion (2016, positive): “enger receptor, which is then followed by heme oxygenase-1 (HO-1)-dependent heme degradation (54, 55, 190, 211, 264, 274, 432, 452, 677, 751, 787).”
Identification of an intestinal heme transporter. (2005, background): “Hemoglobin-haptoglobin uptake takes place in macrophages expressing the CD163 receptor (Kristiansen et al., 2001).”
Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease. (2014, background): “Haptoglobin minimizes heme loss from Hb by transporting Hb to CD163 on macrophages for catabolism.(41) SCD patients have low plasma haptoglobin levels.”
Cell Biology of Ischemia/Reperfusion Injury (2012, background): “Third, Kupffer cells are active in clearing free hemoglobin released from damaged erythrocytes via the CD163 scavenger receptor (Kristiansen et al., 2001), followed by degradation by heme oxygenase-1 (HO-1) (Goda et al., 1998), which is highly expressed in Kupffer cells (Bauer et al., 1998; Genken…”
Structure and function of the spleen (2005, background): “Receptor-mediated endocytosis of CD163, a haemoglobin-specific receptor at the cell surface of macrophage”
Regulatory interactions between muscle and the immune system during muscle regeneration. (2010, background): “haptaglobin (46, 95) and ligation of CD163 can contribute to regulating macrophage phenotype by increasing the expression of anti-inflammatory cytokines, especially IL-10 (86).”
Macrophages: development and tissue specialization. (2015, background): “Their expression of the scavenger receptor CD163 allows endocytosis of hemoglobin– haptoglobin complexes, thereby protecting tissues from free hemoglobin-mediated oxidant injury (154).”
Mechanisms of cell protection by heme oxygenase-1. (2010, background): “In addition, Hp inhibits the pro-oxidant effects of cell-free Hb (195) as well as heme release from cell-free Hb. Recognition of Hb by Hp forms Hb-Hp complexes recognized (KM ∼ 2.10−11–10−12 M) by the Hp receptor (CD163; Q86VB7) (196), which promotes endocytosis of Hb-Hp complexes by hemophagocytic ”