Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease.

By J. Belcher, Chunsheng Chen, J. Nguyen, L. Milbauer, Fuad A. Abdulla, A. Alayash, Ann Smith, K. Nath, R. Hebbel, G. Vercellotti. Blood, 2014

632 citations recorded by the source corpus.

Subfields: Cell Biology, Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/983904eb5bcc0c901036fa73fc1aab7366f919e2

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Citations in the corpus

• Complement System Part I – Molecular Mechanisms of Activation and Regulation (2015, background): “Furthermore, in vitro experiments on human EC have shown that heme-induced mobilization of specific EC granules that store von Willebrand Factor and P-selectin called Weibel Palade bodies, is at least in part induced by TLR4 (102, 103).”