Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance

By Qingchun Tong, C. Ye, Juli E. Jones, J. Elmquist, Bradford B. Lowell. Nature Neuroscience, 2008

664 citations recorded by the source corpus.

The physiologic importance of GABAergic neurotransmission in hypothalamic neurocircuits is unknown. To examine the importance of GABA release from agouti-related protein (AgRP) neurons (which also release AgRP and neuropeptide Y), we generated mice with an AgRP neuron–specific deletion of vesicular GABA transporter. These mice are lean, resistant to obesity and have an attenuated hyperphagic response to ghrelin. Thus, GABA release from AgRP neurons is important in regulating energy balance.

Subfields: Endocrine and Autonomic Systems, Nutrition and Dietetics, Physiology

View Paper: https://www.semanticscholar.org/paper/8da35d7f6e6d3c2daa9da1532caaf20d91b924c9

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Endocrine and Autonomic Systems

1. Bryan L. Roth
2. C. Ye
3. M. Krashes
4. Bradford B. Lowell

In Nutrition and Dietetics

1. Bryan L. Roth
2. Bradford B. Lowell

In Physiology

1. Bradford B. Lowell

Citations in the corpus

• Adult Mouse Cortical Cell Taxonomy by Single Cell Transcriptomics (2016, neutral): “For the full list of recombinase and reporter lines see Supplementary Table 1 19, 20, 32, 52–60 and Supplementary Table 2 56, 58 , respectively.”
• Rapid, reversible activation of AgRP neurons drives feeding behavior in mice. (2011, methodology): “suring oxygen consumption as previously described (4) using a compre-”
• A New DREADD Facilitates the Multiplexed Chemogenetic Interrogation of Behavior (2015, neutral): “, 2005), and the arcuate nucleus (ARC) of Agouti-Related Peptide (AGRP)ires-Cre mice (Tong et al., 2008)(Fig 3A, B, E and F).”
• Leptin Action on GABAergic Neurons Prevents Obesity and Reduces Inhibitory Tone to POMC Neurons (2011, neutral): “To confirm a prominent role for non-AgRP GABAergic neurons, we utilized mice in which AgRP neurons are unable to release GABA (Agrp-ires-Cre, Vgatlox/lox mice (Tong et al., 2008)).”