N-3 polyunsaturated fatty acids in coronary heart disease: a meta-analysis of randomized controlled trials.

By H. Bucher, P. Hengstler, C. Schindler, G. Meier. American Journal of Medicine, 2002

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“The Mediterranean Diet, its Components, and Cardiovascular Disease” (2014, background): “A multitude of meta-analyses have shown a potential cardiovascular disease morbidity and mortality benefit for mainly secondary prevention with increased fish intake (19-28).”
The health benefits of omega-3 polyunsaturated fatty acids: a review of the evidence. (2004, methodology): “When comparing the relative benefits for different types of patients, Bucher et al. (2002) calculated that 250 patients with a low CHD risk would need to be supplemented with n-3 PUFA for 12 years to prevent one premature death.”
n-3 fatty acids and cardiovascular disease. (2006, background): “The relatively immediate benefit and the strongest effect on sudden coronary death suggest that fish oils act to prevent fatal arrhythmias (31).”
Omega-3 Fatty Acids and Inflammatory Processes (2010, background): “Further, marine n-3 PUFAs decrease mortality due to cardiovascular disease [113,114]; this may be, in part, due to stabilization of atherosclerotic plaques against”
Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease. (2002, neutral): “This has been summarized in a recent meta-analysis of 11 RCTs with 7951 patients in the intervention groups.(55) In this meta-analysis, the risk ratio of nonfatal MI was 0.”