The long-chain sphingoid base of sphingolipids is acylated at the cytosolic surface of the endoplasmic reticulum in rat liver.

By K. Hirschberg, Jennifer Rodger, A. Futerman. 1993

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Mammalian Ceramide Synthases (2010, background): “The subcellular location of the CerS proteins is the ER (8, 10, 11, 20, 23, 26, 27), although it should be emphasized that Table 1 Comparison of human CerS”
Lip1p: a novel subunit of acyl‐CoA ceramide synthase (2005, background): “Ceramide synthase has been proposed to have its active site on the cytoplasmic surface of the ER membrane (Hirschberg et al, 1993) because its activity is protease sensitive in isolated microsomal membranes.”
Differential expression of (dihydro)ceramide synthases in mouse brain: oligodendrocyte-specific expression of CerS2/Lass2 (2008, unknown): “24), membrane-bound enzymes of the endoplasmic reticulum (Mandon et al. 1992; Hirschberg et al. 1993).”
(Dihydro)ceramide Synthase 1–Regulated Sensitivity to Cisplatin Is Associated with the Activation of p38 Mitogen-Activated Protein Kinase and Is Abrogated by Sphingosine Kinase 1 (2007, methodology): “Dihydroceramide synthase enzyme assays were done as previously described (20, 22, 27, 45).”