Dissection of key events in tubular epithelial to myofibroblast transition and its implications in renal interstitial fibrosis.

By Junwei Yang, Youhua Liu. American Journal of Pathology, 2001

817 citations recorded by the source corpus.

Subfields: Pulmonary and Respiratory Medicine, Surgery, Urology

View Paper: https://www.semanticscholar.org/paper/8d0b9d74cb746d3971579704eda2bf31b8364f3b

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Pulmonary and Respiratory Medicine

1. Youhua Liu
2. J. P. Thiery
3. J. Sleeman
4. Raghu Kalluri
5. R. Mason
6. Zhi Zhang
7. T. Kamimura
8. H. Kasai

In Surgery

1. Youhua Liu
2. Raghu Kalluri
3. J. P. Thiery
4. M. Nieto

In Urology

1. Youhua Liu
2. Raghu Kalluri

Citations in the corpus

• Cellular and molecular mechanisms of renal fibrosis (2011, background): “Broad agreement exists that tubular epithelial cells in vitro can undergo EMT, characterized by loss of epithelial features and acquisition of mesenchymal markers, under the bombardment of various profibrotic cytokines, particularly TGF-β1”
• TGF-β and epithelial-to-mesenchymal transitions (2005, background): “…cells of renal, pulmonary, or hepatic origins by hypoxic (Manotham et al., 2004) or oxidative stress signals (Rhyu et al., 2005), inflammatory stimuli (Fan et al., 2001), wounding, and metabolic factors (Oldfield et al., 2001) (also reviewed in Yang and Liu, 2001; Kalluri and Neilson, 2003).”
• Role of tissue stroma in cancer cell invasion (2003, background): “During tubulointerstitial fibrosis in the kidney, tubular epithelial cells transdifferentiate to myofibroblasts via a TGF-β-dependent mechanism [138,139].”
• Targeted disruption of TGF-β1/Smad3 signaling protects against renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction (2003, methodology): “Protein extracts from kidneys (6) and cell culture medium were used for the determination of active TGF-β1 with a Quantikine TGF-β1 assay kit (R&D Systems).”
• Epithelial to mesenchymal transition in renal fibrogenesis: pathologic significance, molecular mechanism, and therapeutic intervention. (2004, methodology): “Transforming growth factor– 1 (TGF- 1) as a sole factor is capable of inducing tubular epithelial cells to undergo all four steps (28).”
• Complex networks orchestrate epithelial–mesenchymal transitions (2006, background): “In addition, animal models of kidney disease indicate that EMT occurs in tubular epithelial cell”
• Epithelial-mesenchymal transition and its implications for fibrosis. (2003, background): “Downloaded from http://www.jci.org on April 27, 2017. https://doi.org/10.1172/JCI20530 promoter regions of a group of genes that would be expected in EMT-derived fibroblasts, including those encoding c-myc, c-Fos, H-ras, Slap, TGF-β, FGF-1, -2, and -8, FSP1, vimentin, α-smooth muscle actin (αSMA), a”
• TGF-β1 induces human alveolar epithelial to mesenchymal cell transition (EMT) (2005, background): “Our data is consistent with the findings made in in kidney tubular epithelial cells where MMP-2 and MMP-9 were up-regulated by TGF-β1 in parallel with changes in EMT markers [27,31].”