Targeted disruption of TGF-β1/Smad3 signaling protects against renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction

By Misako Sato, Y. Muragaki, S. Saika, A. Roberts, A. Ooshima. 2003

728 citations recorded by the source corpus.

Subfields: Molecular Biology, Nephrology

View Paper: https://www.semanticscholar.org/paper/b3d246c15802cb1ecaea10cb3b8711ac7bda4335

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Citations in the corpus

Inflammation and EMT: an alliance towards organ fibrosis and cancer progression (2009, background): “Therefore, ON and UUO can be used as a reference for the development of fibrosis, in part because inflammatory responses have been analysed in depth in this model.”
TGF-β/SMAD Pathway and Its Regulation in Hepatic Fibrosis (2016, background): “Knockdown of SMAD3 blocks EMT and attenuates renal fibrosis, inflammation, and apoptosis after unilateral ureteral obstruction (UUO) (Meng et al. 2010; Sato et al. 2003).”
TGF-β/Smad signaling in renal fibrosis (2015, background): “It is well documented that Smad3 is pathogenic since knockout of Smad3 gene inhibits fibrosis in obstructive nephropathy (Sato et al., 2003), diabetic nephropathy (Fujimoto et al., 2003), hypertensive nephropathy (Liu et al., 2012), and drug-toxicity-related nephropathy (Zhou et al., 2010).”
Transforming growth factor–β in tissue fibrosis (2020, background): “TGF-β–driven EMT has been implicated in the pathogenesis of fibrosis in several different organs, including the kidney (Sato et al., 2003), liver (Rygiel et al.”
Smad3 as a mediator of the fibrotic response (2004, background): “There is also evidence that sphingolipid mediators play a role in regulating TGF-b signalling, as cotransfection of Smad3 and sphingosine 1-phosphate phosphatase in fibroblasts caused a dramatic increase in COL1A2 promoter activity (Sato et al. 2003a).”
TGF-β signaling in fibrosis (2011, background): “Similarly, dermal fibrosis following irradiation (Flanders et al. 2002), renal interstitial fibrosis produced by unilateral ureteral obstruction (Sato et al. 2003), and cardiac fibrosis (Bujak et al. 2007; Dobaczewski et al. 2010a) are all attenuated in Smad3deficient animals.”
The Snail genes as inducers of cell movement and survival: implications in development and cancer (2005, background): “Fibrosis also appears in the kidney concomitant with Snail1 expression after injury, and TGFβ can also mimic this effect both in vitro and in vivo (Sato et al., 2003).”