Epithelial-mesenchymal transition and its implications for fibrosis.

By Raghu Kalluri, Eric G. Neilson. Journal of Clinical Investigation, 2003

2,639 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology, Pulmonary and Respiratory Medicine

View Paper: https://www.semanticscholar.org/paper/538ecdab989cd0f0b55c0c2fb7d912db92cda881

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Citations in the corpus

Epithelial—mesenchymal and mesenchymal—epithelial transitions in carcinoma progression (2007, background): “Epithelial-mesenchymal transitions: Twist in development and metastasis.”
Myocardial remodeling after infarction: the role of myofibroblasts (2010, background): “In addition to pre-existing local fibroblasts that can differentiate into myofibroblasts, epithelial and endothelial cells can adopt a myofibroblast phenotype through the processes of epithelial–mesenchymal transition and endothelial–mesenchymal transition, respectively”
Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition. (2007, background): “Enhanced signaling through TGF-β1, a well-known inducer of EMT, has been observed in response to hypoxia (21, 22).”
Preventing or reducing late side effects of radiation therapy: radiobiology meets molecular pathology (2006, background): “But where do the fibroblasts come from in the first place? Epithelial–mesenchymal transition (EMT) of cells has long been recognized as an important part of embryonic development, but more recent data suggest that EMT occurs during wound healing and fibrogenesis in adult tissue”
TGF-β-induced EMT: mechanisms and implications for fibrotic lung disease (2007, background): “, zonula occludens-1 (ZO-1)] and E-cadherin due to disassembly of cell-cell contacts}, cytoskeletal reorganization, and transition to a spindle-shaped morphology concomitant with acquisition of mesenchymal markers [including -smooth muscle actin ( -SMA)] and an invasive phenotype (35, 115, 118).”
Pathophysiology of Acute Kidney Injury (2012, positive): “This led to the suggestion that fibroblasts derive from epithelial cells via a process called epithelial mesenchymal transition (EMT), contributing to the development of interstitial fibrosis (245).”
TGF-β1 induces human alveolar epithelial to mesenchymal cell transition (EMT) (2005, background): “Thus, one possible role of TGF-β1 in IPF is to induce or promote epithelial cells in injured alveolar epithelium to undergo EMT [15], as is evident from studies of other fibrotic disorders such as renal fibrosis [10,11,14].”
Cellular and molecular mechanisms of fibrosis (2008, background): “More recently, it was suggested that a similar process occurs with endothelial cells, termed endothelial–mesenchymal transition (EndMT) [13].”