Chemistry for peptide and protein PEGylation.

By M. J. Roberts, M. Bentley, J. M. Harris. Advanced Drug Delivery Reviews, 2002

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The dawning era of polymer therapeutics (2003, background): “First-generation protein conjugates used linear monomethoxyPEGs and a variety of conjugation chemistrie”
Surface Plasmon Resonance: A Versatile Technique for Biosensor Applications (2015, background): “Investigators have developed numerous covalent conjugation chemistries to produce protein-linker conjugates [89–91].”
PEGylation of therapeutic proteins (2010, background): “Hence it is important to pay attention to suitable PEGylation chemistry, solution conditions and careful selection of the PEGylation site [37].”
Recent advances in rational gene transfer vector design based on poly(ethylene imine) and its derivatives (2005, background): “Modification of PEI with PEG can be accomplished using different synthetic strategies [84].”