The dawning era of polymer therapeutics

By R. Duncan. Nature reviews. Drug discovery, 2003

3,021 citations recorded by the source corpus.

Subfields: Biomaterials, Molecular Biology, Organic Chemistry

View Paper: https://www.semanticscholar.org/paper/804ec35ccf4fe44c43b355dcd974625a4d8738b4

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Citations in the corpus

RNA interference in the clinic: challenges and future directions (2010, background): “Polymer and dendrimer drug conjugates have followed suit, and many different formulations are currently under clinical investigatio”
Exploiting the enhanced permeability and retention effect for tumor targeting. (2006, neutral): “and Duncan, R. (2006) Polymer conjugates: nanosized medicines for”
Computationally Guided Photothermal Tumor Therapy Using Long-Circulating Gold Nanorod Antennas (2009, methodology): “We chose a PEG polymer coating due to the widespread clinical use of variable-length PEG polymers for extending the circulation time of protein therapeutics (23, 24) and for nanoparticle formulations, such as the drug-loaded liposomes Doxil.”
Effects of nanomaterial physicochemical properties on in vivo toxicity (2009, neutral): “Traditional polymer drug delivery systems utilize linear, random-coil polymers such as polyethylene glycol, N-(2-hydroxypropyl) methacrylaminde copolymers, poly (ethyleneimine), poly(lactic acid), poly(glycolic acid) and their copolymers, dextrin (α-1, 4 polyglucose), hyaluronic acid, chitosans, pol”
Thermo- and pH-responsive polymers in drug delivery. (2006, background): “Polymer therapeutics are here divided into 5 subclasses: polymeric drugs, polymer-drug conjugates, polymer– protein conjugates, polymeric micelles and polyplexes (complexes of polymers and poly(nucleic acids)) [1,2].”
A review of current nanoparticle and targeting moieties for the delivery of cancer therapeutics (2012, neutral): “Two of the most important properties of effective nanocarriers are the carriers’ ability to (a) remain circulating in the blood stream for a significant amount of time and (b) target specific tissues and cells (Duncan, 2003).”