PEGylation of therapeutic proteins

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Assessment of the Evolution of Cancer Treatment Therapies (2011, background): “Modified versions, such as PEGylation of fragments (modification of a molecule by linking of one or more polyethylene glycol chains) [44] to improve circulation half-life, glycosylation and Fc region engineering are some of the recent approaches used by researchers to overcome these problems [45].”
PEGylation of Biopharmaceuticals: A Review of Chemistry and Nonclinical Safety Information of Approved Drugs. (2016, neutral): “Adagen®, pegadamase 96-126 5 [11-17] Patient d”
An overview of active and passive targeting strategies to improve the nanocarriers efficiency to tumour sites (2019, background): “On the other hand, imidazole groups-([68,69]) or poly(b-amino ester)based([70]) polymers responsive to tumoral low pH as well as polymers having pH-sensitive chemical linkages, like acetal,([71]) hydrazine,([72,73]) vinyl and ortho esters,([74]) pHsensitive cell-penetrating peptides and cationic pol”