STATs in oncogenesis

By Tammy L. Bowman, R. Garcia, J. Turkson, R. Jove. Oncogene, 2000

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Stat proteins and oncogenesis. (2002, background): “Salient examples are seen in multiple myeloma, which characteristically overexpresses IL-6 and its receptor, and in head and neck cancers, where EGF and its receptor are found at high levels (29).”
STAT proteins: novel molecular targets for cancer drug discovery (2000, background): “…(Besser et al., 1999), v-Ros (Zong et al., 1998), v-Fps (Garcia et al., 1997), Etk/ BMX (Wen et al., 1999), and Lck (Lund et al., 1999; Yu et al., 1997), all activate Stat3 in the context of oncogenesis (for reviews see Bowman et al., 2000b; Catlett-Falcone et al., 1999a; Garcia and Jove, 1998).”
Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis (2002, background): “Although tyrosine kinases signal through multiple pathways, Stat3 is a point of convergence for many of these (Bowman et al., 2000; Bromberg and Darnell, 2000; Catlett-Falcone et al., 1999a).”
STAT proteins: From normal control of cellular events to tumorigenesis (2003, background): “This contradiction has been explained by Bowman et al. (2000) with the fact that p21 is also responsible for the correct assemblage of the D1/CDK cyclin complex, and thus its increase may be necessary for cell-cycle progression.”
Role of Src expression and activation in human cancer (2000, background): “Each of these events alone may be capable of enhancing tumor growth (Bowman et al., 2000).”