Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis

By G. Niu, K. Wright, Meijuan Huang, Lanxi Song, Eric B. Haura, J. Turkson, Shumin M. Zhang, Tianhong Wang, D. Sinibaldi, D. Coppola and 7 more. Oncogene, 2002

1,244 citations recorded by the source corpus.

Subfields: Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/2a8315c7cc15c206fcb29de525fa0fe88087f917

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

In Oncology

Citations in the corpus

Mechanisms of immune evasion by tumors. (2006, background): “Constitutive activation of Stat3 in tumor cells has been shown to upregulate cell cycle regulatory, proangiogenic and antiapoptotic genes critical to the transformation process (Bowman et al., 2001; Bromberg et al., 1999; Niu et al., 2002; Turkson et al., 1998).”
Targeting the STAT3 signaling pathway in cancer: role of synthetic and natural inhibitors. (2014, background): “It was shown that human breast cancer, head and neck carcinoma, melanoma [182], pancreatic cancer [122] and cervi-”
STAT proteins: From normal control of cellular events to tumorigenesis (2003, background): “Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis.”
Dangerous liaisons: STAT3 and NF-κB collaboration and crosstalk in cancer (2009, background): “Conditional STAT3 inactivation in hematopoietic cells revealed that the effect of STAT3 on tumor angiogenesis originates from its function in myeloid suppressor dendritic cells (MDSC) and tumor associated macrophages (TAM) (79,81).”
An epigenetic switch involving NF-κB, Lin28, let-7 microRNA, and IL6 links inflammation to cell transformation (2009, positive): “These high levels of IL6 depend on both transcriptional activation by NF-kB and inhibition of Let7 and are required for sufficient binding to the IL6 receptor to cause phosphorylation and nuclear entry of the STAT3 transcription factor, which then activates multiple growth and survival genes such as”
Vascular Endothelial Growth Factor and Angiogenesis (2004, background): “Niu et al. (2002) showed that constitutively activated Stat3 is capable of activating VEGF expression.”
IL-6 in inflammation, autoimmunity and cancer (2020, background): “The IL-6–STAT3 pathway is involved in the epithelial–mesenchymal transition (EMT) (131, 132), tumor migration (133), cancer stemness (130, 134, 135) and the induction of hypoxia-inducible factor-1 α (HIF-1 α ) and vascular endothelial growth factor (VEGF), two key players for angiogenesis (136–140).”